金钗石斛中1个新的异香木兰烷型倍半萜成分

A new allo-aromadendrane sesquiterpene from Dendrobium nobile

研究金钗石斛Dendrobium nobile茎中非生物碱部分的化学成分。运用大孔吸附树脂、MCI、硅胶、反相C_(18)、Sephadex LH-20凝胶柱色谱、制备薄层色谱及制备型高效液相色谱等技术进行化合物的分离纯化,根据理化性质、波谱数据结合参考文献鉴定化合物结构。从金钗石斛茎中分离得到8个化合物,分别为soltorvum F(1)、对羟基苯丙酸(2)、香草酸(3)、对羟基苯甲酸(4)、N-反式桂皮酸酰对羟基苯乙胺(5)、(+)-(1R,2S,3R,4S,5R,6S,9R)-2,11,12-trihydroxypicrotoxane-3(15)-lactone(6)、dendronobilin H(7)、soltorvum E(8)。其中化合物1为新化合物,命名为soltorvum F,化合物8为首次从石斛属中分离得到。

To study the chemical constituents in the non-alkaloid part of stems of Dendrobium nobile.The macroporous adsorption resin,MCI,silica gel,RP-C_(18),and Sephadex LH-20 gel,preparative thin layer chromatography,and preparative high-performance liquid chromatography(HPLC) were used to isolate and purify the compounds.The structures of the compound were determined according to the spectra data,physicochemical properties,and relevant references.A total of 8 compounds were isolated from D.nobile,which were soltorvum F(1),p-hydroxyphenylpropionic acid(2),vanillic acid(3),p-hydroxybenzoic acid(4),N-trans-cinnamic acid acyl-p-hydroxybenzene ethylamine(5),(+)-(1R,2S,3R,4S,5R,6S,9R)-2,11,12-trihydroxypicrotoxane-3(15)-lactone(6),dendronobilin H(7),soltorvum E(8).Compound 1 was a novel compound,named as soltorvum F.Compound 8 was isolated from Dendrobium species for the first time.