普瑞巴林联合利多卡因治疗带状疱疹后遗神经痛的临床疗效观察

Clinical Efficacy of Pregabalin Combined with Lidocaine in the Treatment of Post Herpetic Neuralgia

目的:评价普瑞巴林口服联合利多卡因外用治疗带状疱疹后遗神经痛(PHN)的临床疗效。方法:回顾性分析2019年12月—2022年12月就诊于宜昌市中心人民医院的72例PHN患者的临床资料,随机分为对照组(n=36)和试验组(n=36)。两组患者均口服普瑞巴林,试验组患者后遗神经痛部位联合外用利多卡因凝胶贴膏,记录治疗前后视觉模拟量表(VAS)评分、睡眠质量评分及不良反应发生情况,对比两组患者的临床疗效。结果:两组患者治疗后VAS评分均呈下降趋势,治疗后2周(3.50±1.08 vs 4.50±1.36)、4周(1.75±0.69 vs 2.86±0.90)及6周(0.78±0.68 vs 1.33±0.76)试验组VAS评分均低于对照组(均P<0.05)。治疗后6周两组患者的睡眠质量评分均较前明显降低,且试验组患者的睡眠质量评分低于对照组(9.50±2.85 vs 11.81±2.73,P<0.05)。两组不良反应主要为恶心、头晕及共济失调,但两组不良反应发生率无统计学差异(69.44%vs 80.56%,P>0.05)。结论:普瑞巴林联合利多卡因治疗PHN临床疗效好,可显著降低疼痛程度并改善睡眠质量。

Objective:To evaluate the clinical effect of oral pregabalin combined with topical lidocaine in the treatment of post herpetic neuralgia(PHN).Methods:The clinical data of 72 patients with PHN admitted to Yichang Central People's Hospital from December 2019 to December 2022 were retrospectively analyzed.They were randomly divided into the control group(n=36)and the experimental group(n=36).Patients in both groups were given oral pregabalin,and patients in the experimental group were combined with topical lidocaine gel paste at the site of residual neuralgia.Visual analog scale(VAS),sleep quality score and occurrence of adverse reactions were recorded before and after treatment,and the clinical efficacy of the two groups were compared.Results:VAS score in both groups showed a downward trend after treatment.The VAS score of the experimental group were lower than those of the control group at 2 weeks(3.50±1.08 vs 4.50±1.36),4 weeks(1.75±0.69 vs 2.86±0.90)and 6 weeks(0.78±0.68 vs 1.33±0.76)after treatment(all P<0.05).The sleep quality score of both groups were significantly lower than before,and the sleep quality score of the experimental group was lower than the control group at 6 weeks after treatment(9.50±2.85 vs 11.81±2.73,P<0.05).The main adverse reactions were nausea,dizziness and ataxia,but there was no significant difference between the two groups(69.44%vs 80.56%,P>0.05).Conclusion:Pregabalin combined with lidocaine has good clinical efficacy in the treatment of PHN,which can significantly reduce pain degree and improve sleep quality.