丁苯酞联合益气活血汤治疗气虚血瘀证脑梗死早期神经功能恶化研究

Study of butylphthalide combined with Yiqi Huoxue decoction in the treatment of early neurological deteriora⁃tion of cerebral infarction patients with Qi deficiency and blood stasis type

目的 研究丁苯酞联合益气活血汤治疗气虚血瘀证脑梗死早期神经功能恶化患者疗效及安全性。方法选择120例气虚血瘀证脑梗死早期神经功能恶化患者,采用随机数字表法分为观察组和对照组,各60例。观察组给予丁苯酞联合益气活血汤治疗,对照组给予常规治疗。治疗2周后,比较两组的疗效、美国国立卫生研究院卒中量表(NIHSS)评分、Barthel指数、血清C反应蛋白(CRP)、D-二聚体差异。结果 观察组治疗总有效率明显高于对照组,差异有统计学意义(χ^(2)=4.62,P<0.05)。治疗后,两组患者NIHSS评分、血清CRP、D-二聚体明显降低,Barthel指数明显升高(t分别=11.30、27.97、60.80、-9.64;17.15、37.98、103.90、-12.26,P均<0.05),且观察组患者治疗后NIHSS评分、血清CRP、D-二聚体明显低于对照组,Barthel指数明显高于对照组,差异均有统计学意义(t分别=5.98、14.66、103.90、-3.57,P均<0.05)。结论 丁苯酞联合益气活血汤可明显改善气虚血瘀证脑梗死早期神经功能恶化患者的神经功能、血清CRP、D-二聚体,其疗效高于传统治疗方法,具有高效安全等优点。

Objective To study the efficacy and safety of butylphthalide combined with Yiqi Huoxue decoction in the treatment of early neurological deterioration in cerebral infarction patients with Qi deficiency and blood stasis type.Methods A total of 120 patients with early neurological deterioration of cerebral infarction with Qi deficiency and blood stasis type were selected and randomly divided into an observation group and a control group,with 60 cases in each group.The observation group was treated with butylphthalide combined with Yiqi Huoxue decoction,while the control group was given routine treatment.After 2 weeks of treatment,the differences in efficacy,NIHSS score,Barthel index,serum C-reactive protein(CRP),and D-dimer between the two groups were compared.Results The total effective rate of the observation group was significantly higher than that of the control group,and the difference was statistically significant(χ^(2)=4.62,P<0.05).After treatment,the NIHSS score,serum CRP,D-dimer were significantly reduced and the Barthel index was signifi⁃cantly increased in both groups of patients(t=11.30,27.97,60.80,-9.64,17.15,37.98,103.90,-12.26,P<0.05).Moreover,the NIHSS score,serum CRP,D-dimer in the observation group were significantly lower than those in the control group,while the Barthel index was significantly higher than those in the control group,the differences were statistically significant(t=5.98,14.66,103.90,-3.57,P<0.05).Conclusion The combination of butylphthalide and Yiqi Huoxue decoction can significantly improve the early deterioration of neurological function in Qi deficiency and blood stasis type,as well as the neurological function,serum CRP,and D-dimer in cerebral infarction.Its curative effect is higher than traditional treatment methods,and it has the advantages of high efficiency and safety.