中药调控JAK/STAT信号通路干预心肌缺血再灌注损伤作用机制研究进展

Research Progress in the Mechanism of TCM for Regulating JAK/STAT Signaling Pathway in Intervention of Myocardial Ischemia-reperfusion Injury

急性心肌梗死是临床常见的心血管急危重症,早期再灌注是治疗急性心肌梗死的常规有效方法,但血液供应的恢复可能造成心肌缺血再灌注损伤(MI/RI),从而加重心肌损伤。近年来研究发现,中药在干预MI/RI方面具有多成分、多途径、多靶点的独特优势。Janus酪氨酸蛋白激酶/信号转导及转录激活因子(JAK/STAT)信号通路与MI/RI密切相关,通过调控炎症、氧化应激、细胞增殖、分化、凋亡等作用减轻MI/RI进程。本文就JAK/STAT信号通路在MI/RI中的作用机制及靶向调控该通路的中药研究进行综述,以期为MI/RI的防治及药物研发提供参考。

Acute myocardial infarction(AMI)is a common cardiovascular emergency in clinic.Early reperfusion is a typical and effective method for the treatment of AMI.However,the recovery of blood supply after reperfusion therapy will accelerate the damage of ischemic myocardium and cause myocardial ischemia-reperfusion injury(MI/RI).In recent years,studies have found that TCM has the unique advantages of multi-component,multichannel and multi-target in the intervention of MI/RI.Janus tyrosine kinase/signal transducer and activator of transcription(JAK/STAT)signaling pathway is closely related to MI/RI,which can reduce MI/RI process by regulating inflammation,oxidative stress,cell proliferation,differentiation and apoptosis.This article reviewed the mechanism of JAK/STAT signaling pathway in MI/RI and the research of TCM targeting this pathway,in order to provide references for the prevention and treatment of MI/RI and further drug development.