胰岛素不同给药方法治疗对急诊糖尿病酮症酸中毒患者不良反应及效果的影响

Effects of Different Insulin Administration Methods on Adverse Reactions and Outcomes of Patients with Emergency Diabetic Ketoacidosis

目的探究急诊糖尿病酮症酸中毒患者运用胰岛素不同给药方法治疗的效果及不良反应发生率。方法回顾性分析2020年11月—2022年11月龙岩市第一医院急诊科收治的82例糖尿病酮症酸中毒患者的临床资料,根据用药方式不同分为两组,各41例。对照组:胰岛素静脉滴注用药,观察组:胰岛素持续微量泵注用药,比较治疗情况。结果观察组的相关治疗指标均优于对照组,差异有统计学意义(P<0.05)。治疗前两组血糖水平比较,差异无统计学意义(P>0.05);治疗后,观察组血糖水平低于对照组,差异有统计学意义(P<0.05)。治疗后,观察组氧化应激指标优于对照组,差异有统计学意义(P<0.05)。治疗后,观察组患者的生活质量优于对照组,差异有统计学意义(P<0.05)。观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。观察组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论在急诊糖尿病酮症酸中毒患者治疗中,胰岛素不同的给药方式会产生不同的效果,其中持续微量泵注给药的效果明显要优于静脉滴注给药,而且还能减少不良反应,安全性较高。

Objective To investigate the effect and the incidence of adverse reactions in patients with emergency dia-betic ketoacidosis treated by different administration methods of insulin.Methods The clinical data of 82 patients with diabetic ketoacidosis admitted to the emergency department of Longyan First Hospital from November 2020 to November 2022 were retrospectively analyzed,and they were divided into two groups with forty-one cases each ac-cording to different medication methods.Control group:insulin intravenous infusion,observation group:insulin con-tinuous micro-pump injection.The treatment were compared between the two groups.Results The relevant therapeu-tic indexes in the observation group were better than those in the control group,and the differences were statistically significant(P<0.05).There was no statistically significant difference in blood glucose level before treatment(P>0.05).After treatment,blood glucose level in observation group was lower than that in control group,and the difference was statistically significant(P<0.05).After treatment,the oxidative stress index of the observation group was better than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the quality of life of the observation group was lower than that of the control group,and the difference was statistically significant(P<0.05).The total effective rate of the observation group was higher than that of the control group,and the difference was statis-tically significant(P<0.05).The incidence of adverse reactions in observation group was lower than that in control group,and the difference was statistically significant(P<0.05).Conclusion In the treatment of patients with emer-gency diabetic ketoacidosis,different administration modes of insulin will produce different effects,among which the effect of continuous micro-pump administration is obviously better than intravenous administration,and it can reduce adverse reactions and has high safety.