摘要
2型糖尿病(T2DM)患者比正常人更容易发生脑小血管病(CSVD),且对认知功能的损害有明确的关联。多元醇途径亢进、血管神经单元(NVU)的破坏、胰岛素抵抗和过度的氧化应激反应等是可能是其发病机制。本文对T2DM致CSVD发生发展的可能机制、T2DM伴CSVD的影像学特征及两者相关并发症的影响等进行综述,以促进对CSVD发病机制的探索及为特定的治疗提供线索。
Patients with type 2 diabetes mellitus(T2DM)are more prone to cerebral small vessel disease(CSVD)than normal people,and there is a clear correlation between CSVD and cognitive impairment.The pathogenesis may be due to the hyperfunction of polyol pathway,the destruction of vascular nerve unit(NVU),insulin resistance and excessive oxidative stress reaction.This article reviews the possible mechanism of CSVD caused by T2DM,the imaging characteristics of T2DM with CSVD and the impact of their related complications,so as to promote the exploration of the pathogenesis of CSVD and provide clues for specific treatment.
作者
杨家怡
王浩川
李亚楠
王靖茹
李红芳
YANG Jiayi;WANG Haochuan;LI Yanan;WANG Jingru;LI Hongfang(Clinical Medical College of Jining Medical University,Jining,Shandong 272000,China;不详)
出处
《中国临床研究》
CAS
2023年第12期1895-1898,共4页
Chinese Journal of Clinical Research
基金
济宁市重点研发计划项目(2022YXNS051)。
关键词
脑小血管病
2型糖尿病
影像学特征
多元醇途径亢进
血管神经单元
胰岛素抵抗
氧化应激反应
Cerebral small vessel disease
Type 2 diabetes mellitus
Imaging features
Hyperactivity of polyol pathway
Vascular nerve unit
Insulin resistance
Oxidative stress response
