红藤败酱散加减联合氟罗沙星片治疗慢性盆腔炎临床研究

Clinical Study on Modified Caulis Sargentodoxae and Herba Patriniae Powder Combined with Fleroxacin Tablets in the Treatment of Chronic Pelvic Inflammatory Disease

目的:观察红藤败酱散加减氟罗沙星片治疗慢性盆腔炎的临床疗效及其对患者炎性因子水平、血液流变学指标的影响。方法:将82例慢性盆腔炎患者按照随机数字表法分为观察组和对照组,每组各41例。对照组给予氟罗沙星片治疗,观察组在对照组治疗的基础上联合红藤败酱散加减。比较两组患者的临床疗效、不良反应发生率及治疗前后中医证候积分、炎性因子水平[白细胞介素(interleukin, IL)-1β、超敏C反应蛋白(hs-C reactive protein, hs-CRP)、IL-2、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)]、血液流变学指标[纤维蛋白原(fibrinogen, FIB)、血沉、全血低切黏度]变化情况。结果:两组患者治疗后中医证候积分低于本组治疗前,且治疗后观察组低于对照组(P<0.05)。观察组有效率为97.56%,高于对照组的82.93%(P<0.05)。两组患者治疗后hs-CRP、IL-1β、IL-2、TNF-α、FIB、血沉及全血低切黏度均低于本组治疗前,且治疗后观察组低于对照组(P<0.05)。观察组不良反应发生率为14.63%,对照组不良反应发生率为9.76%,组间比较,差异无统计学意义(P>0.05)。结论:红藤败酱散加减联合氟罗沙星片治疗慢性盆腔炎,可缓解患者的临床症状,降低炎性因子水平及血液流变学指标。

Objective: To observe the clinical efficacy of Modified Caulis Sargentodoxae and Herba Patriniae Powder combined with fleroxacin tablets on chronic pelvic inflammatory disease and the influence on inflammatory factors and hemorheology indexes.Methods: A total of 82 patients with chronic pelvic inflammatory disease were randomly divided into the observation group and the control group according to the number table method, with 41 cases in each group.The control group was treated with Fleroxacin Tablets, while the observation group was supplemented with Modified Caulis Sargentodoxae and Herba Patriniae Powder on the basis of the control group.The clinical efficacy, incidence of adverse reactions, the changes in TCM syndrome scores, inflammatory factor levels [including interleukin(IL)-1β,hs-C reactive protein,(hs-CRP),IL-2,tumor necrosis factor-α(TNF-α)],hemorheology indexes [includingfibrinogen(FIB),erythrocyte sedimentation rate(ESR),whole blood low shear viscosity] before and after treatment were compared between the two groups.Results: After treatment, the TCM syndrome scores of the two groups were lower than those before treatment, and the observation group′s TCM syndrome scores were lower than those of the control group(P<0.05).The effective rate of the observation group was 97.56%,which was higher than that of the control group(82.93%)(P<0.05).Hs-CRP,IL-1β,IL-2,TNF-α,FIB,ESR and whole blood low viscosity after treatment were all lower than those before treatment, and the observation group′s above indexes were lower than those of the control group(P<0.05).The incidence of adverse reactions was 14.63% in the observation group and 9.76% in the control group respectively, and there was no statistical significance between the two groups(P>0.05).Conclusion: In the treatment of chronic pelvic inflammatory disease, Modified Caulis Sargentodoxae and Herba Patriniae Powder combined with Fleroxacin Tabletscan alleviate the clinical symptoms, reduce the levels of inflammatory factors and hemorheology indexes.