肺癌患者术后医院感染的危险因素研究

Risk factors of postoperative nosocomial infection in lung cancer patients

目的研究医院胸外科住院肺癌患者的医院感染发生率及肺癌患者术后发生医院感染的危险因素。方法选取2021年1-12月重庆医科大学附属第一医院收治的肺癌术后患者2280例作为研究对象,对患者的临床资料进行回顾性研究。结果2280例肺癌患者的医院感染发生率为4.12%(94/2280);以下呼吸道感染为主,占87.23%(82/94)。多因素logistic回归分析显示,男性发生医院感染风险明显高于女性(OR=2.279,95%CI:1.362~3.814,P=0.002),≥60岁人群发生医院感染风险明显高于<60岁人群(OR=1.905,95%CI:1.132~3.206,P=0.015);与住院时间<7 d的肺癌患者比较,住院时间为7~<15 d、15~<22 d、22~28 d和>28 d的患者发生医院感染风险更高,OR值依次为3.252(95%CI:1.251~8.453,P=0.016)、12.134(95%CI:4.482~32.851,P<0.001)、43.198(95%CI:14.891~125.319,P<0.001)和121.015(95%CI:39.435~371.359,P<0.001)。结论男性、高龄、住院时间较长是肺癌患者术后发生医院感染的独立危险因素。

Objective To investigate the incidence of nosocomial infection in lung cancer patients in thoracic surgery and the risk factors of postoperative nosocomial infection in lung cancer patients.Methods A total of 2 280 postoperative patients with lung cancer admitted in the department of thoracic surgery,the First Affiliated Hospital of Chongqing Medical University from January 2021 to December 2021 were selected as the research objects,and the clinical data of the patients were analyzed retrospectively.Results The incidence of nosocomial infection in 2 280 lung cancer patients was 4.12%(94/2 280),and the infection site was mainly in the lower respiratory tract,accounting for 87.23%(82/94).Multivariate logistic regression analysis showed that the risk of nosocomial infection was significantly higher in males than in females(OR=2.279,95%CI:1.362-3.814,P=0.002).The risk of nosocomial infection in people aged ≥60 years was significantly higher than that in people aged <60 years(OR=1.905,95%CI:1.132-3.206,P=0.015).Compared with lung cancer patients with a hospital stay of <7 days,patients with a hospital stay of 7-<15 days,15-<22 days,22-28 days and >28 days had a higher risk of nosocomial infection,with OR values of 3.252(95%CI:1.251-8.453,P=0.016),12.134(95%CI:4.482-32.851,P<0.001),and 43.198(95%CI:14.891-125.319,P<0.001),and 121.015(95%CI:39.435-371.359,P<0.001).Conclusion Male,old age and longer hospital stay are independent risk factors for postoperative nosocomial infection in lung cancer patients.