基于数据挖掘的国医大师吕仁和教授运用脾胃经中药分期治疗糖尿病经验研究

Study on Staging Treatment of Diabetes with Traditional Chinese Medicine for Spleen and Stomach Meridian by Professor LYU Renhe Based on Data Mining

目的:通过分析国医大师吕仁和教授分期治疗糖尿病的医案处方,探索吕仁和教授运用脾胃经中药分期治疗糖尿病的相关用药规律。方法:收集吕仁和教授门诊糖尿病处方,进行频数分析、关联规则分析、聚类分析。结果:共纳入285份病历处方,其中脾瘅期6份、消渴期70份、消瘅期209份;频数分析得到各期脾胃经中药频次前5位分别为:脾瘅期:黄芩、生甘草、茵陈、黄芪、白芍;消渴期:生甘草、白芍、枳壳、枳实、知母;消瘅期:太子参、枳实、生甘草、黄芪、当归。对消渴期和消瘅期高频用药进行关联规则分析,消渴期、消瘅期各得到6组脾胃经中药组合;通过聚类分析,消渴期得到脾胃经中药聚类4类,消瘅期得到5类。结论:吕仁和教授分期治疗糖尿病,注重恢复脾胃和降运化功能,采取调补之法,不同分期脾胃经中药选择及配伍各有特点。

Objective:By analyzing the prescription of Professor LYU Renhe in treating diabetes by stages,this paper explored the related medication law of Professor LYU in the staging treatment of diabetes with traditional Chinese medicine for spleen and stomach meridians.Methods:The frequency analysis,association rule analysis,and cluster analysis were carried out by collecting the prescriptions of Professor LYU Renhe for diabetes.Results:A total of 285 medical records were included,with six involving the Pidan stage,70 involving the Xiaoke stage,and 209 involving the Xiaodan stage.Frequency analysis found that the top five frequencies of traditional Chinese medicine for spleen and stomach meridians in the three stages were Pidan stage:Scutellaria,raw Glycyrrhizae Radix et Rhizoma,Artemisiae Scopariae Herba,Radix Astragalus,and Paeoniae Radix Alba;Xiaoke stage:raw Glycyrrhizae Radix et Rhizoma,Paeoniae Radix Alba,Fructus Aurantii,Aurantii Fructus Immaturus,and Rhizoma Anemarrhenae;Xiaodan stage:Pseudostellariae Radix,Aurantii Fructus Immaturus,raw Glycyrrhizae Radix et Rhizoma,Radix Astragalus,and Angelica.Association rules of drugs with high use frequency in the Xiaoke and Xiaodan stages were analyzed,and six combinations of traditional Chinese medicine for spleen and stomach meridians were obtained during the Xiaoke and Xiaodan stages.After cluster analysis,four combinations of traditional Chinese medicine for spleen and stomach meridians during the Xiaoke stage and five combinations of traditional Chinese medicine for spleen and stomach meridians during the Xiaodan stage were obtained.Conclusion:Professor LYU Renhe pays attention to the recovery of the spleen and stomach and the function of reducing movement in the treatment of diabetes by stages and adopts the method of regulating and replenishment.The selection and compatibility of traditional Chinese medicine for spleen and stomach meridians in different stages have their own characteristics.