从免疫炎症角度论针灸治疗慢性荨麻疹的效应机制

Discussion on Effect Mechanism of Acupuncture in the Treatment of ChronicUrticaria from the Perspective of Immunoinflammation

慢性荨麻疹(CU)是临床皮肤科常见的疾病之一,以突发性风团和红斑,伴有不同程度的瘙痒,或血管性水肿为主要表现,具有多发性、反复性、迁延性的临床特点,给患者生活带来极大困扰。其发病机制尚不明确,不少学者认为免疫系统失衡是引发慢性荨麻疹的主因。针灸在临床实践中已被广泛证明是治疗CU的有效手段。文献梳理显示,针灸能够通过多靶点调动机体免疫系统,抑制肥大细胞脱颗粒,降低自身抗体水平,减少炎症介质释放,纠正免疫细胞失衡,同时针刺皮肤可抑制皮损局部免疫细胞募集,减少炎症细胞浸润,促进机体自我修复,改善CU患者临床症状。

Chronic urticaria(CU)is one of the common diseases in clinical dermatology,with sudden wheals and erythema,accompanied by varying degrees of itching,or angioedema as the main manifestations.It has multiple,recurrent,and prolonged clinical characteristics,bringing great trouble to the patient′s life.Its pathogenesis is still unclear,and many scholars believe that the imbalance of the immune system is the main cause of CU.Acupuncture has been widely proven to be an effective means of treating CU in clinical practice.Through literature review,acupuncture can mobilize the body′s immune system through a variety of targets,inhibit mast cell degranulation,reduce autoantibody levels and the release of inflammatory mediators,and correct immune cell imbalance.In addition,acupuncture of the skin can inhibit the aggregate of local immune cells in skin lesions and reduce inflammatory cell infiltration,thereby promoting self-repair and improving the clinical symptoms of CU patients.