急性前壁心肌梗死早期室壁瘤形成的心脏磁共振成像特征

Cardiac Magnetic Resonance Characteristics and Risk Factors of Early Formed Ventricular Aneurysm After Emergency Percutaneous Coronary Intervention in Patients With Acute Anterior Myocardial Infarction

目的:探究急性前壁心肌梗死患者早期室壁瘤[急性心肌梗死后2周内心脏磁共振成像(CMR)下发现的室壁瘤]形成的CMR特征。方法:对接受直接经皮冠状动脉介入治疗并在两周内完成CMR的108例急性前壁心肌梗死患者进行回顾性分析,按是否形成早期室壁瘤分为非室壁瘤组(n=72)和室壁瘤组(n=36)。将获得的CMR图像导入CVI42软件进行图像分析,建立Logistic回归分析模型,获取诊断早期室壁瘤的CMR参数。结果:室壁瘤组较非室壁瘤组的年龄和钆延迟增强(LGE)面积更大,左心功能和心肌应变更差。多因素Logistic回归分析显示,LGE面积(OR=1.32,95%CI:1.071~1.628,P=0.009)、心尖角(OR=1.24,95%CI:1.041~1.475,P=0.016)、间壁二尖瓣环平面收缩期位移(间壁MAPSE,OR=0.36,95%CI:0.169~0.757,P=0.007)和整体纵向应变(GLS,OR=0.53,95%CI:0.154~0.953,P=0.046)与早期室壁瘤形成相关。ROC曲线分析显示,LGE面积、心尖角、间壁MAPSE和GLS的AUC分别为0.922、0.921、0.905和0.814,最佳临界值分别为28.5%、90°、8.245 mm和10.155%。结论:使用CMR技术结合CVI42软件估测LGE面积、心尖角、间壁MAPSE和GLS可以帮助诊断急性前壁心肌梗死患者早期室壁瘤的形成。

Objectives:To explore the cardiac magnetic resonance(CMR)features of early ventricular aneurysm formation in patients with acute anterior myocardial infarction.Methods:One hundred and eight patients with acute anterior myocardial infarction who underwent primary percutaneous coronary intervention and completed CMR scans within two weeks were retrospectively analyzed and divided into non-ventricular aneurysm group(n=72)and ventricular aneurysm group(n=36)according to the absence or presence of early ventricular aneurysm after primary percutaneous coronary intervention.The obtained CMR images were imported into CVI42 software for image analysis,and a logistic regression analysis model was established to evaluate CMR features useful for the diagnosis of early ventricular aneurysm formation.Results:Aging and larger area of late gadolinium enhancement(LGE)and worse left ventricular systolic function and lower myocardial strain were features of patients in the ventricular aneurysm group as compared to the non-ventricular aneurysm group.LGE area(OR=1.32,95%CI:1.071-1.628,P=0.009),apical angle(OR=1.24,95%CI:1.041-1.475,P=0.016),septal mitral annular plane systolic excursion(septal MAPSE,OR=0.36,95%CI:0.169-0.757,P=0.007)and global longitudinal strain(GLS,OR=0.53,95%CI:0.154-0.953,P=0.046)were associated with early ventricular aneurysm formation.ROC curves were analyzed for the above four CMR parameters,and the AUC were 0.922,0.921,0.905,and 0.814,respectively.The optimal cutoff values were 28.5%,90°,8.245 mm,and 10.155%,respectively.Conclusions:Estimation of LGE area,apical angle,septal MAPSE and GLS using CMR technique can help diagnose early ventricular aneurysm in patients with acute anterior myocardial infarction.