MDT综合治疗对消化道恶性肿瘤患者免疫功能及心理状态的影响

Effect of multidisciplinary team (MDT) combined therapyon immune function and psychological state of patients with gastrointestinal tumors

目的 探讨多学科团队模式(Multidisciplinary team, MDT)对消化道恶性肿瘤患者免疫功能及心理状态的影响。方法 选取2021年3月-2021年8月于重庆海吉亚医院普外科收治的120例消化道恶性肿瘤患者为研究对象,采用随机数字表法分为试验组与对照组,每组60例。对照组行常规诊疗模式,由普外科医师主导所有检查和治疗决策。试验组在对照组基础上采用MDT治疗,由多个科室医生共同参与患者的检查和治疗决策。比较两组患者干预前后免疫功能(CD3+T和CD4+T淋巴细胞比例)、心理状态(焦虑、抑郁评分)的变化以及3年生存率。结果 两组患者入院后免疫功能及心理状态比较,差异无统计学意义(P>0.05)。与对照组干预后相比,试验组CD3+T与CD4+T淋巴细胞比例均升高,焦虑、抑郁评分降低,差异有统计学意义(P<0.05)。1年生存率试验组较对照组提高16.6%,3年生存率试验组较对照组提高20%。结论 对消化道恶性肿瘤患者进行MTD综合治疗,可有效减少焦虑抑郁情绪、改善心理状态,进而提高患者免疫功能和长期生存率。

Objective To explore the impact of multidisciplinary team(MDT)model on the immune function and psychological state of patients with gastrointestinal malignant tumors.Methods120 patients with digestive tract malignant tumors admitted to the hospital from March 2021 to August 2021 were selected as the research subjects.The patients were divided into experimental group and control group using the random number table method,with 60 cases in each group.The control group received routine diagnosis and treatment,with general surgeons taking the lead in all examinations and treatment decisions.The experimental group received MDT treatment on the basis of the control group,and the doctors from multiple departments participated in the patient′s examination and treatment decisions.The changes in immune function(proportion of CD3+T and CD4+T lymphocytes),psychological state(anxiety and depression scores)and 3-year survival rate of the 2 groups of the patients before and after intervention were compared.ResultsThere was no statistically significant difference in the immune function and psychological status of the two groups of patients after theadmission(P>0.05).Compared with the control group after intervention,the proportion of CD3+T and CD4+T lymphocytes in the experimental group wasincreased,and the anxiety and depression scores weredecreased,and the difference was statistically significant(P<0.05).The 1-year survival rate of the experimental group was 16.6%higher than that of control group,and the 3-year survival rate of experimental group was 20%higher than that of control group.ConclusionMTD comprehensive treatment for patients with digestive tract malignant tumors can effectively reduce anxiety and depression,improve the psychological state,and thereby improve the patient′s immune function and long-term survival rate.