阿奇霉素在治疗小儿肺炎支原体感染中的临床价值

Clinical Value of Azithromycin in the Treatment of Mycoplasma Pneumoniae Infection in Children

目的探讨对小儿肺炎支原体感染患儿采用阿奇霉素药物完成治疗后获得临床效果。方法选取2020年2月—2023年5月无锡市锡山人民医院门诊收治的80例小儿肺炎支原体感染患儿作为研究对象;以随机数表法进行分组;施以克林霉素棕榈酸酯分散片药物治疗的设为参照组(n=40);施以阿奇霉素治疗的设为研究组(n=40);对比两组小儿肺炎支原体感染患儿的治疗总有效率、临床症状改善情况(咳嗽消失时间、退热时间、喘息消失时间以及肺部湿啰音消失时间)以及不良反应(腹痛、恶心、呕吐以及腹泻)总发生率。结果研究组治疗总有效率高于参照组,差异有统计学意义(P<0.05);研究组咳嗽消失时间(4.15±1.72)d、退热时间(2.99±0.36)d、喘息消失时间(5.51±1.43)d以及肺部湿啰音消失时间(2.46±0.25)d短于参照组的(6.99±1.97)、(4.95±1.33)、(7.07±1.45)、(5.39±1.13)d,差异有统计学意义(t=14.123、8.996、4.844、16.011,P<0.05);研究组不良反应总发生率低于参照组,差异有统计学意义(P<0.05)。结论临床对小儿肺炎支原体感染患儿采用阿奇霉素药物完成治疗后,可将治疗效果显著提升,将咳嗽消失时间、退热时间、喘息消失时间以及肺部湿啰音消失时间有效缩短,使腹痛、恶心、呕吐以及腹泻等不良反应发生率显著降低,从而对小儿肺炎支原体感染患儿的良好预后给予明显促进。

Objective To explore the clinical effect of azithromycin in children with mycoplasma pneumoniae infection.Methods 80 cases of children admitted to the outpatient department of Wuxi Xishan People's Hospital from February 2020 to May 2023 were selected as the research objects;Grouping by the random number table method;Drugs treated with clindamycin palmitate dispersing tablets were set as the reference group(n=40);Those treated with azithromycin were assigned as the study group(n=40);The total incidence of treatment response rate,improvement of clinical symptoms(disappearance time of cough,fever,wheezing,and lung wet rales),and the overall incidence of adverse effects(abdominal pain,nausea,vomiting,and diarrhea)were compared.Results The total response rate of the study group was higher than the reference group,and the difference was statistically significant(P<0.05);Time of cough disappearance(4.15±1.72)d,time of antipyretic(2.99±0.36)d,time of wheezing(5.51±1.43)d,and time of wet rale disappearance(2.46±0.25)d of the study group were shorter than the reference group(6.99±1.97)d,(4.95±1.33)d,(7.07±1.45)d,(5.39±1.13)d,and the differences were statistically significant(t=14.123,8.996,4.844,16.011,P<0.05);The overall incidence of adverse reactions in the study group was lower than that in the reference group,and the difference was statistically significant(P<0.05).Conclusion Clinical treatment of children with mycoplasma pneumoniae infection with azithromycin can significantly improve the therapeutic effect,effectively shorten the disappearance time of cough,fever,wheezing and lung moist rales,and significantly reduce the incidence of adverse reactions such as abdominal pain,nausea,vomiting and diarrhea.Therefore,the good prognosis of children with mycoplasma pneumoniae infection was significantly promoted.