同型半胱氨酸、尿酸与糖尿病视网膜病变相关性的研究进展

Research progress on the relationship between homocysteine,uric acid and diabetic retinopathy

糖尿病视网膜病变属于糖尿病的血管性并发症,同型半胱氨酸是蛋氨酸代谢的中间产物。高同型半胱氨酸血症可直接或间接损伤血管内皮细胞,使血管内皮细胞发生功能障碍,从而参与糖尿病视网膜病变的发生发展。尿酸是嘌呤代谢的最终产物,高尿酸血症可引起血管内皮功能失调、氧化代谢及血小板黏附、聚集功能异常,从而参与糖尿病视网膜病变的发生发展。近年来,对糖尿病视网膜病变和同型半胱氨酸、尿酸水平的相关性已有较多研究,该文就国内外相关文献予以综述,以期为糖尿病视网膜病变的预防和治疗提供新的信息。

Diabetic retinopathy is a vascular complication of diabetes,and homocysteine is an intermediate product of methionine metabolism.Hyperhomocysteinemia can directly or indirectly damage vascular endothelial cells,causing vascular endothelial cells dysfunction and participating in the occurrence and development of diabetic retinopathy.Uric acid is the final product of purine metabolism.Hyperuricemia can cause vascular endothelial dysfunction,oxidative metabolism,platelet adhesion and aggregation dysfunction,thus participating in the occurrence and development of diabetic retinopathy.In recent years,there have been many studies on the correlation between diabetic retinopathy and levels of homocysteine and uric acid.This article reviews the relevant literature at home and abroad in order to provide new information for the prevention and treatment of diabetic retinopathy.