胰岛移植部位的研究现状

Research status of islet transplantation site

胰岛移植部位可分为原位胰岛移植和异位胰岛移植两大类。原位胰岛移植指从移植胰岛所分泌释放的胰岛素,通过肝门静脉系统入肝代谢,没有改变原来的胰岛素代谢途径,包括肝脏的门静脉系统、大网膜等部位的胰岛移植。异位胰岛移植所分泌的胰岛素改变了其原有的代谢途径。理想的胰岛移植部位一般具备以下特点:移植的成功率高同时移植物远期存活率高、手术操作简单创伤小、并发症少,同时风险小,便于重复检测等特点。该文就对胰岛移植部位的研究现状作一综述,以为后续相关研究提供借鉴。

The islet transplantation site can be divided into two categories:orthotopic islet transplantation and ectopic islet transplantation.Orthotopic islet transplantation refers to that the insulin secreted and released from the transplanted islet will be metabolized into the liver through the hepatic portal vein system,which does not change the original insulin metabolic pathway,including the portal vein of the liver,the greater omentum.The insulin secreted by the ectopic islet transplantation changes the original metabolic pathway of insulin.The ideal islet transplantation site generally has the following characteristics:high success rate transplantation,high long-term survival rate of graft,simple operation,less trauma,less complications,low risk,easy to repeat detection and so on.This article provides a review of the current research status of each islet transplantation site,in order to provide reference for future related research.