金属有机框架基水凝胶复合材料修复软硬组织损伤的潜力和优势

Potential and advantages of metal organic frameworks-based hydrogel materials for repairing soft and hard tissues

背景:由于单纯水凝胶材料存在机械性能差、药物释放不稳定及功能单一等问题,近年来,研究者通过在水凝胶中引入金属有机框架制备了多种金属有机框架基水凝胶复合材料,并在软硬组织修复领域展现出巨大的潜力。目的:以金属有机框架在金属有机框架基水凝胶材料中的作用对该复合材料进行分类,进一步归纳其在软硬组织修复领域的研究进展,以期为后续对该复合材料合成机制和临床应用的深入研究提供思路与理论支持。方法:在Web of Science、PubMed、中国知网和万方数据库中,以“金属有机框架,水凝胶,组织工程,组织,骨再生,骨,伤口”为中文检索词,以“Metal organic frameworks,Hydrogels,Tissue engineering,Tissue,Bone regeneration,Bone,Wound”为英文检索词进行文献检索,检索时间范围为2000年1月至2023年8月。通过阅读文题和摘要进行初步筛选,排除中英文文献重复性研究及内容不相关的文献,经文献质量评价后,最后纳入73篇文献进行综述。结果与结论:(1)金属有机框架基水凝胶材料有效解决单纯水凝胶材料机械性能差、药物释放不稳定、功能单一的问题;(2)金属有机框架通过加强水凝胶交联、增强水凝胶药物递送能力和赋予水凝胶多种功能以提高水凝胶修复软硬组织能力;(3)在硬组织修复方面,在骨缺损、骨关节炎和骨软骨缺损等疾病的动物模型中表现出良好的修复效果,提示其在临床修复中具有潜在的应用前景;(4)在软组织修复方面,能发挥止血、抗菌、调节炎症状态、调节氧化应激状态及促进血管生成等多种功能,有效改善各类复杂伤口的微环境,促进软组织再生;(5)尽管金属有机框架基水凝胶材料具有许多优异的性能,但目前尚处于起步阶段,在向临床转化的过程中仍存在一些亟待解决的难题,例如金属有机框架的细胞毒性及金属有机框架的大规模合成等;(6)随着研究的进一步深入,金属有机框架基水凝胶材料在软硬组织修复领域具有广阔的应用前景。

s,the repetitive studies and unrelated literature of Chinese and English literature were excluded.After the literature quality evaluation,73 articles were included for review.RESULTS AND CONCLUSION:(1)Metal organic frameworks-based hydrogel materials effectively solve the problems of poor mechanical properties,unstable drug release and single function of pure hydrogel.(2)Metal organic frameworks enhance the capacity of repair and regeneration by strengthening the crosslinking of hydrogel,the drug delivery capacity of hydrogel and the multifunction of hydrogel.(3)In terms of hard tissue repair,it has shown good repair effects in animal models of diseases such as bone defects,osteoarthritis,and cartilage defects,suggesting potential application prospects in clinical repair.(4)In terms of soft tissue regeneration,it has the capacities of hemostasis,antibacterial,inflammatory state regulation,oxidative stress state regulation,promoting angiogenesis and other functions,effectively improving the microenvironment of various complex wounds and promoting soft tissue regeneration.(5)Although metal organic frameworks-based hydrogels have many excellent properties,they are still in the initial stage and there are some urgent problems to be solved in the process of clinical transformation,such as the cytotoxicity of metal organic frameworks and large-scale synthesis of metal organic frameworks.(6)With further research,metal organic frameworks-based hydrogels have broad application prospects in the field of soft and hard tissue repair.