摘要
布比卡因是临床上广泛使用的长效局部麻醉药,但是,对于手术后需要数天镇痛的患者,其6~8 h的作用时效尚不能满足临床需求。设计药物剂型可以延长局部麻醉药的作用时效或减小其毒性。将局部麻醉药包封在药物输送系统中可以为手术患者提供长效镇痛。2011年,美国食品药品管理局(FDA)批准了一种基于DepoFoam TM技术的多泡布比卡因脂质体注射液,该制剂时效可达72 h以上。该文综述了布比卡因脂质体注射液的临床安全性研究和应用于手术后镇痛的研究进展。
Bupivacaine is a long-acting local anesthetic widely used clinically,but its 6-8 hours duration is insufficient for postoperative analgesia.Designing drug dosage forms to prolong the action time of local anesthetics is the research content of local anesthetics.In 2011,the FDA approved a bupivacaine liposome preparation based on DepoFoam TM technology:Exparel,which can be used for more than 72 hours.This article reviewed the clinical safety research of Exparel and the research progress of its application in clinical postoperative analgesia.
作者
徐鑫
汪小海
汤春艳
陈洁
葛卫红
XU Xin;WANG Xiaohai;TANG Chunyan;CHEN Jie;GE Weihong(Department of Anesthesiology,Nanjing Drum Tower Hospital Affiliated to Medical College of Nanjing University,Nanjing 210008,China;Department of Anesthesiology,the Affiliated Taikang Xianlin Drum Tower Hospital of Nanjing University,Nanjing 210046,China;Department of Pharmacy,Nanjing Drum Tower Hospital Affiliated to Medical College of Nanjing University,Nanjing 210008,China)
出处
《医药导报》
CAS
北大核心
2024年第1期91-96,共6页
Herald of Medicine
关键词
布比卡因脂质体注射液
长效制剂
脂质体
手术后镇痛
Bupivacaine liposome injection
Long-acting preparation
Liposome
Postoperative analgesia