基于“肾-肝-脑”轴探讨围绝经期健忘的中医防治

TCM prevention and treatment of perimenopausal amnesia based on"kidney-liver-brain"axis

围绝经期健忘是女性特殊生理时期发生的脑记忆功能减退的表现,严重影响女性的生活质量,且可能增加阿尔茨海默病(Alzheimer's disease,AD)发生的风险。健忘归属于中医学“呆症”范畴。基于肝肾母子相生的生理和女性围绝经期肾虚肝郁引起健忘发生的特点,本文首次提出“肾-肝-脑”轴及围绝经期健忘之概念,同时阐述养阴宁神方补肾滋肝以防治围绝经期健忘的重要作用,以期为中医防治围绝经期健忘提供理论基础。

Manifested as decreased cerebral memory function in women's special physiological period,perimenopausal amnesia severely affects their quality of life and may increase the risk of Alzheimer's disease(AD).Amnesia belongs to the category of"dementia"in Chinese medicine.Based on the physiological relationship of mutual help and mutual assistance between the liver(child)and the kidney(mother)as well as the susceptibility to amnesia in perimenopausal women due to kidney deficiency and liver qi stagnation,this paper first proposes the concepts of"kidney-liver-brain"axis and perimenopausal amnesia.It also elaborates the importance of Yangyin Ningshen Formula in tonifying the kidney and nourishing the liver for the prevention and treatment of perimenopausal amnesia,so as to provide a theoretical basis for TCM prevention and treatment of perimenopausal amnesia.