SMARCA2缺失的未分化肠癌4例并文献复习

SMARCA2⁃deficient undifferentiated bowel cancer:a report of 4 cases and literature review

目的探究SMARCA2缺失的未分化肠癌这一组特殊类型肿瘤的临床病理学特征。方法收集2016年1月至2020年12月在威海市立医院诊断为未分化肠癌并且SMARCA2阴性的病例资料,由高年资医师重新检查苏木精-伊红(HE)染色切片,观察其组织学形态,再次确定未分化形态。使用自动免疫组化染色机对患者的甲醛固定石蜡包埋的组织块提取的代表性切片进行免疫组织化学染色。结果共入组4例病例,均于1年内死亡,HE切片下表现为高度恶性的形态。结论SMARCA2缺失是一种预后差的指标,其可能是肿瘤去分化过程的一环。对SMARCA2在这类肿瘤的确切作用和作用机制尚未明确。SMARCA2作为一种潜在的治疗靶点,也可能是一种评价预后的标志物,具有一定研究价值。

Objective To explore the clinicopathological features of SMARCA2⁃deficient undifferentiated bowel cancer.Methods Clinical data of patients with undifferentiated bowel cancer and negative SMARCA2 expression diagnosed in Weihai Municipal Hospital during Jan.2016 and Dec.2020 were collected.The sections of HE staining were re⁃exam⁃ined,the histological morphology was re⁃observed,and the undifferentiated morphology was re⁃determined by senior pathologists.The representative sections extracted from paraffin⁃embedded formalin⁃fixed tissue blocks were stained with automatic immunohistochemical staining machine.Results All four patients died within 1 year.HE staining showed highly malignant morphology.Conclusion SMARCA2 depletion is an indicator of poor prognosis and may be involved in tumor dedifferentiati.