癌细胞膜仿生载体在肿瘤治疗中的研究进展

Research progress of biomimetic carrier of cancer cell membrane in tumor therapy

肿瘤治疗一直都是研究的重点,由于肿瘤细胞的多变性、肿瘤微环境的复杂性等因素,造成了肿瘤的多药耐药性、药物的递送效率降低等问题。近年来,仿生载体受到越来越多的关注,其中癌细胞膜(cancer cell membrane, CCM)是一种具有同源靶向性、免疫逃逸、可穿透生物屏障等特点的新型纳米载体,以CCM作为仿生载体包裹不同类型纳米粒子(nanoparticles, NPs)可实现有效的肿瘤靶向,在肿瘤治疗中具有一定的优势。本综述介绍了CCM仿生载体,简述了CCM包裹NPs的制备过程,总结了CCM在肿瘤药物递送和肿瘤疫苗中的研究,讨论了CCM未来的发展前景。

Tumor therapy has always been the focus of study.Due to the variability of tumor cells,the complexity of the tumor microenvironment and other factors,the problems such as multidrug resistance of tumors,reduced drug delivery efficiency are obtained.In recent years,increasing attention has been paid to biomimetic vectors,in which cancer cell membrane(CCM)is a new type of nano⁃carrier with the characteristics of homologous targeting,immune escape and penetrating biological barrier.Using CCM as a bionic carrier to coat different types of nanoparticles(NPs)can achieve effective tumor targeting and advantages in tumor therapy.This review introduces the biomimetic vector of CCM,briefly describes the preparation process of NPs coated with CCM,summarizes the research of CCM in tumor drug delivery and tumor vaccine,and discusses the future development prospects of CCM.