纳米纤维素基水凝胶在生物医学领域的研究进展

Research Progress of Nanocellulose-based Hydrogels for Biomedical Applications

纳米纤维素具有高比表面积(150~250 m^(2)/g)、大长径比、低密度(1.6 g/cm^(3))和优越的机械性能(弹性模量~150 GPa,高拉伸强度~7.5 GPa)等特性,在生物医学等领域有着广泛的应用。本文主要对近几年纳米纤维素基水凝胶的研究进展进行了归纳总结。首先介绍了纳米纤维素的制备方法,包括机械法、酸水解法、TEMPO(2,2,6,6⁃四甲基哌啶⁃1⁃氧化物自由基)氧化法和生物法;其次列举了制备纳米纤维素基水凝胶的常用交联方法,包括物理交联和化学交联;最后重点介绍了纳米纤维素基水凝胶在生物医学领域方面的应用,包括伤口敷料、组织工程和药物输送;此外,对纳米纤维素基水凝胶在生物医学领域的发展方向进行了展望。

Nanocellulose has been widely used in biomedical and other fields because of its high specific surface area(150~250 m^(2)/g),large aspect ratio,low density(1.6 g/cm^(3))and excellent mechanical properties(elastic modulus~150 GPa,high tensile strength~7.5 GPa).This paper mainly summarized the research progress of nanocellulose-based hydrogels in recent years.Firstly,the preparation methods of nanocellulose were introduced,including mechanical,acid hydrolysis,TEMPO oxidation and biological methods.Secondly,the common cross-linking methods of nanocellulose-based hydrogels,including physical crosslinking and chemical crosslinking,were listed.Finally,the applications of nanocellulose-based hydrogels in biomedical fields,including wound dressings,tissue engineering and drug delivery,were introduced.In addition,the development direction of nanocellulose-based hydrogels in biomedical field was prospected.