Comments on‘Downregulation of hepatic ceruloplasmin ameliorates NAFLD via SCO1–AMPK–LKB1 complex’

Human health requires macronutrients,such as amino acids,glucose,and lipids,as well as micronutrients,including copper and iron.Copper is required for the assembly of various enzymes,such as copper/zinc superoxide dismutase and cytochrome c oxidase(Kim et al.,2008).It has been well documented that adenosine monophosphate-activated protein kinase(AMPK)senses intracellular glucose concentrations(Li et al.,2019),mTOR is responsible for monitoring intracellular amino acid levels(Liu and Sabatini,2020),and CD36 functions as a sensor for intracellular lipid amounts(Hao et al.,2020).However,it is still unclear how intracellular copper dynamic changes are sensed and whether copper plays a crucial messenger role in the regulation of metabolism of macronutrients.