长效干扰素在费城染色体阴性骨髓增殖性肿瘤中的研究进展

Progress of long-acting interferon in Philadelphia chromosome-negative myloproliferative neoplasms

费城染色体阴性骨髓增殖性肿瘤(MPN),是一类由造血干细胞克隆性增生引起的慢性血液系统肿瘤,羟基脲为传统的一线化疗药物。近年来,聚乙二醇干扰素在MPN治疗实践中体现出较大的优势,已经成为年轻患者及妊娠期妇女等特殊人群治疗的一线优选方案。

Philadelphia chromosome-negative myeloproliferative neoplasms(MPN)is a group of chronic hematological tumors caused by clonal proliferation of hematopoietic stem cells,and hydroxyurea is the traditional first-line chemotherapy drug for it.In recent years,pegylated interferon has shown great advantages in the clinical treatment of MPN,and it has become the first-line preferred therapeutic regimen for special populations,especially for young patients and pregnant women.