摘要
转录因子Ascl1可将体细胞重编程为诱导神经元,包括将成纤维细胞、星形胶质细胞、Müller胶质细胞等体细胞重编程为不同的神经元亚型(多巴胺能神经元、氨基酸类神经元等)。该过程的机制较为繁琐复杂,其中涉及了分级机制及转录水平的变化。该文主要对Ascl1诱导体细胞重编程为神经元的研究展开综述。
The transcription factor Ascl1 can reprogram fibroblasts,astrocytes,Müller glial cells and other somatic cells into multiple subtypes of induced neurons,including dopaminergic neurons,amino acid neurons,etc.The complex mechanism involved in this process includes hierarchical mechanism and changes in transcription level.This article reviews the research on reprogramming of somatic cell into neurons induced by Ascl1.
作者
张莹丹
陈莉
Zhang Yingdan;Chen Li(Department of Neurology,First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China)
出处
《华中科技大学学报（医学版）》
CAS
CSCD
北大核心
2023年第6期873-877,共5页
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
基金
国家自然科学基金资助项目(No.81760217)。
