线粒体调控在阿尔茨海默病铁死亡中的作用研究进展

Research Advances of Mitochondrial Regulation in Ferroptosis in Alzheimer's Disease

铁死亡(ferroptosis)是一种近年被新定义的程序性细胞死亡形式,与凋亡、坏死等经典细胞死亡方式不同,其特征是细胞内铁积累和严重的脂质过氧化以及典型的线粒体形态功能变化。线粒体级联反应造成的氧化应激和神经元死亡是阿尔茨海默病(Alzheimer’s disease,AD)发病机制中的重要一环,该文主要归纳了细胞中铁代谢以及线粒体内脂代谢、氨基酸代谢异常在AD神经元铁死亡中的作用及机制研究进展。

Ferroptosis,a newly defined programmed cell death,is different from classic apoptosis and necrosis.It is characterized by intracellular iron accumulation,severe lipid peroxidation,and typical mitochondrial morphological and functional changes.Mitochondrial cascade reactions inducing oxidative stress and neuronal death are important events during the pathogenesis of Alzheimer's disease(AD).This review mainly summarized research advances of the role and mechanism of intracellular iron metabolism,mitochondrial lipid metabolism and amino acid metabolism abnormalities in neuron ferroptosis during progress of AD.