复合酸联合中药倒模治疗痤疮炎症后色素沉着的疗效和安全性

Efficacy and safety of compound acid combined with Chinese medicinal liniment pourmask in treatment of pigmentation after acne

目的探讨复合酸联合中药倒模治疗痤疮炎症后色素沉着的疗效和安全性。方法2020年10月至2021年10月,安徽中医药大学第一附属医院皮肤科治疗痤疮炎症后色素沉着患者96例[男34例,女62例,年龄18~53(27.4±7.3)岁],采用随机数字表分为联合组(复合酸联合中药倒模)、复合酸组、中药倒模组,每组32例。复合酸2周1次,中药倒模每周2次,共8周。分别在疗程后2周及4周比较3组色素沉着程度评分及总有效率,并记录每组的不良反应。结果疗程后2周及4周随访,3组患者的色素沉着程度评分均有所下降,差异有统计学意义(P<0.05)。联合组在疗程后2周及4周的总有效率分别为68.75%(22/32)、96.88%(31/32),均高于复合酸组及中药倒模组(均P<0.05)。复合酸组及中药倒模组总有效率比较,差异无统计学意义(P>0.05)。结论复合酸联合中药倒模治疗痤疮后色素沉着的疗效确切,安全性较好,值得临床应用。

Objective To evaluate the clinical efficacy and safety of compound acid combined with Chinese medicinal liniment pourmask in the treatment of pigmentation after acne.Methods From October 2020 to October 2021,the Department of Dermatology,the First Affiliated Hospital of Anhui College of Traditional Chinese Medicine divided 96 patients with pigmentation after acne inflammation,34 males,62 females,aged 18-53(27.4±7.3)years,into a joint group(compound acid combined with Chinese medicinal liniment pourmask,n=32),compound acid group(n=32)and Chinese medicinal liniment pourmask group(n=32).Compound acid was used once every 2 weeks,Chinese medicinal liniment pourmask twice a week,a total of 8 weeks.The clinical efficacy of 2 weeks and 4 weeks after treatment was different from that before treatment(P<0.05).The pigmentation degree score and the total efficacy of each group were assessed at 2 weeks and 4 weeks after the end of treatment.The occurrence of adverse reactions in each group during the treatment cycle was also recorded.Results After 2 weeks and 4 weeks of follow-up after the course of treatment,the pigmentation score of the three groups of patients decreased,and the difference was statistically significant(P<0.05).The total effective rates of the combined group were 68.75%(22/32)and 96.88%(31/32)at 2 and 4 weeks after treatment respectively,both were higher than that of the compound acid group and Chinese medicinal liniment pourmask group(P<0.05).There was no significant difference in total effective rate between compound acid group and Chinese medicinal liniment pourmask group(P>0.05).Conclusions The efficacy of compound acid combined with Chinese medicinal liniment pourmask group in the treatment of pigmentation after acne is remarkable and the safety is good,and therefore it is worth promoting.