米诺环素辅以含青刺果油和酸浆提取物等屏障特护霜治疗玫瑰痤疮的效果

Efficacy of minocycline hydrochloride combined with cream containing prickle oil and purslane extract in treatment of rosacea

目的观察米诺环素辅以含青刺果油和酸浆提取物等屏障特护霜,治疗红斑毛细血管扩张型、丘疹脓疱型玫瑰痤疮的疗效。方法2020年8月至2021年4月,于上海交通大学医学院附属第九人民医院皮肤科就诊的玫瑰痤疮患者44例,男28例、女16例,年龄20~56(37±7)岁。以随机数字表法分为观察组(米诺环素+屏障特护霜)和对照组(米诺环素+凡士林软膏)各22例。评估两种方法的治疗效果,并观察不良反应。结果用药8周后,观察组有效21例,占95.5%;对照组有效16例,占72.7%,观察组疗效优于对照组,差异有统计学意义(χ^(2)=2.06,P=0.039)。两组均未见明显不良反应。结论米诺环素+含青刺果油和酸浆提取物等屏障特护霜治疗玫瑰痤疮有较好的效果,值得临床应用。

Objective To observe the efficacy of minocycline combined with barrier cream containing prickly thorn fruit oil and acid slurry extract in the treatment of patients with erythematous telangiectasia or papular pustular rosacea.Methods From August 2020 to April 2021,44 patients with rosacea were admitted to the Department of Dermatology,the Ninth People′s Hospital,including 28 males and 16 females,aged 20-56(37±7)years.They were randomly divided into the observation group(minocycline plus barrier cream)and the control group(minocycline plus vaseline ointment),with 22 patients in each group.Results After 8 weeks of medication,21 cases(95.5%)in the observation group were effective,while 16 cases(72.7%)in the control group were effective.The efficacy of the observation group was better than that of the control group,the difference was statistically significant(χ^(2)=2.06,P=0.039).No significant adverse reactions were observed in both groups.Conclusions Minocycline combined with barrier cream containing prickly thorn oil and acid slurry extract has a good therapeutic effect on rosacea,which is worthy popularizing.