苯磺酸左旋氨氯地平与缬沙坦联合治疗高血压的临床效果分析

Clinical effect of levamlodipine besylate combined with valsartan in the treatment of hypertension

目的分析苯磺酸左旋氨氯地平与缬沙坦联合治疗高血压的临床效果。方法将2019年10月—2021年10月期间本院诊疗的100例高血压患者作为研究对象。依据不同治疗方案将其分为参考组50例(缬沙坦治疗)和研究组50例(缬沙坦联合苯磺酸左旋氨氯地平治疗)。比较两组的临床疗效、治疗前后的血压水平、治疗后生活质量评分及用药期间的不良反应发生率。结果治疗后,两组血压水平均有所降低,且研究组均优于参考组,组间比较差异均有统计学意义(t=5.652、5.320,均P<0.05);研究组的治疗总有效率高于参考组,组间比较差异有统计学意义(χ^(2)=4.332,P<0.05);研究组各生活质量评分均高于参考组,组间比较差异均有统计学意义(t=5.866、8.167、5.739、7.087,均P<0.05);研究组不良反应发生率略高于参考组,但组间比较差异无统计学意义(χ^(2)=0.177,P>0.05)。结论对于高血压疾病的治疗,单一使用缬沙坦的疗效存在一定的局限性,联合使用苯磺酸左旋氨氯地平,可发挥协同作用,疗效更加显著,有利于改善患者血压水平及生活质量,且安全性好,值得推广与应用。

Objective To analyze the clinical effect of levamlodipine besylate combined with valsartan in the treatment of hypertension patients.Methods From October 2019 to October 2021,100 hypertensive patients were taken as research subjects.They were divided into 50 cases in the reference group(valsartan treatment)and 50 cases in the study group(valsartan combined with levamlodipine benzenesulfonate treatment)based on different treatment plans.The clinical efficacy,blood pressure levels pre-and post-treatment,post-treatment quality of life scores,and the incidence of adverse reactions during the medication period were compared between the two groups.Results After treatment,the blood pressure levels of both groups were reduced,and the study group was better than the reference group,with statistically significant differences in all intergroup comparisons(t=5.652,5.320,both P<0.05);the total effective rate of treatment in the study group was higher than that of the reference group,with statistically significant differences in intergroup comparisons(χ^(2)=4.332,P<0.05);all the quality of life scores in the study group were higher than those of the reference group,and the differences between the groups were all statistically significant(t=5.866,8.167,5.739,7.087,all P<0.05);the incidence rate of adverse reactions in the study group was slightly higher than that of the reference group,but the differences between the groups were not statistically significant(χ^(2)=0.177,P>0.05).Conclusion The efficacy of single use of valsartan has some limitations,and the combined with levamlodipine besylate can play a synergistic effect for hypertension patients.The efficacy is more significant,and is conducive to the improvement of the patient’s blood pressure level and the quality of life,and the safety of the patients,it is worthy of promotion and application.