摘要
Antibacterial extract-coated catheters are promising alternatives to their conventional counterparts,but their hemocompatibility and thermal stability must be studied.Nosocomial bacteria have developed resistance to conventional antibiotics.Herein,the minimum inhibitory but non-hemolytic concentration(MIC-NH)and the thermal stability of Larrea tridentata(L.tridentata)and Origanum vulgare(O.vulgare)extract-coated catheters were studied.Besides,plasma pretreatment was performed to enhance the extract adhesion.Briefly,the extract-coated catheters prevent Staphylococcus aureus colonization without causing hemolysis by using L.tridentata and O.vulgare extracts at MIC-NH(5000 and 2500μg ml~(-1),respectively).Moreover,it has been discovered that the extract coating and plasma treatment improved the thermal stability and the extract adhesion,respectively.Thus,this study provides evidence of alternative antibacterial but non-hemolytic extract-coated catheters.
基金
the grant(No.CVU 859503)given to the first author to pursue his doctorate in Materials Science and Technology at the Autonomous University of Coahuila(UAdeC)
FONCYT-Fund Destined to Promote the Development of Science and Technology in the State of Coahuila(No.COAH-2020-C14-C058)。
