基于静息态功能磁共振成像的无先兆偏头痛局部一致性和低频振幅的研究

Regional Homogeneity and Amplitude of Low-frequency Fluctuation in Patients with MWoA:A Resting-State Functional Magnetic Resonance Imaging Study

目的利用rs-fMRI研究无先兆偏头痛(MwoA)患者脑功能的变化特征。方法对26例MwoA患者和26例健康人行rs-fMRI检查。使用局部一致性(ReHo)和低频振幅(ALFF)评价大脑自发活动,把两组信号明显差异的脑区作为感兴趣区(ROIs),计算ROIs与全脑的功能连接(FC),评估两组脑网络水平活动的差异。采用相关性分析研究两组差异脑区的ReHo值、ALFF值和FC值与病程、发作频率、发病持续时间及偏头痛相关量表的关系。结果患者组在双侧颞下回、右侧舌回的smReHo值增高,左侧岛盖部额下回的smReHo值减低,左侧颞下回的mALFF值增高,左侧岛盖部额下回、右内侧额上回的mALFF值减低;FC分析发现患者组存在全脑功能连接的异常。相关分析显示头痛的发作频率、头痛持续时间以及MIDAS评分与患者组的多个脑区的指标值存在正相关关系。结论MwoA患者存在多个功能活动异常的脑区,可以作为MWoA病情严重程度的评价指标,为深入了解MwoA患者的大脑特征提供了客观的依据。

Objective rs-fMRI was used to characterize changes in brain function in patients with migraine without aura(MwoA).Methods rs-fMRI was performed on 26 patients with MwoA and 26 healthy people.Spontaneous brain activity was evaluated using local consistency(ReHo)and low-frequency amplitude(ALFF),brain regions with significantly different signals between the two groups were used as regions of interest(ROIs),functional connectivity(FC)between ROIs and the whole brain was calculated,and the difference in horizontal activity of brain networks between the two groups was evaluated.Correlation analysis was used to study the relationship between ReHo value,ALFF value and FC value of different brain regions in the two groups with disease course,attack frequency,duration of onset and migraine correlation scale.Results In the patient group,the smReHo value of bilateral inferior temporal gyrus and right lingual gyrus increased,the smReHo value of the left insular operculum decreased the mALFF value,the mALFF value of the left inferior temporal gyrus increased,and the mALFF value of the left insular inferior frontal gyrus and the right medial frontal gyrus decreased.FC analysis found that the patient group had abnormal functional connections throughout the brain.Correlation analysis showed a positive correlation between headache frequency,headache duration,and MIDAS scores and index values of multiple brain regions in the patient group.Conclusion MwoA patients have multiple brain regions with abnormal functional activity,which can be used as an evaluation index for the severity of MWoA disease,and provide an objective basis for in-depth understanding of the brain characteristics of MwoA patients.