正常成人中脑导水管层面脑脊液流动MRI测量:与年龄和性别相关分析

MRI Measurement of Midbrain Aqueductal Cerebrospinal Fluid Flow in Normal Adults:Analysis with Age and Gender

目的对不同年龄、性别的正常成人的中脑导水管层面的脑脊液(CSF)波形、流速和流量进行MRI测量分析比较。方法扫描设备为Philips 1.5T MR,采用中脑导水管MR相位对比法CSF-QF序列扫描,志愿者年龄区间在21-60岁之间,均为健康成年人,分别为21-30岁年龄组、31-40岁年龄组、41-50岁年龄组、51-60岁年龄组,每组20人,每组包含男性和女性各10人,总共为80名志愿者。然后由2名MR操作者使用MR扫描仪自配的流动分析软件,分别独立测量每个志愿者中脑导水管层面脑脊液的流体动力学数据,包括平均流量、平均流速、最大流速。结果所有志愿者中脑导水管层面的脑脊液流量或流速的变化曲线均表现为光滑平整的正弦波形。一致性检验显示2名MR操作者所测量的流体动力学数据的一致性良好(信度系数为0.97-0.99),继而采用2名MR操作者所测量的中脑导水管层面脑脊液的流体动力学数据的平均值做统计学分析。分析表示在各年龄组内,其男性与女性脑脊液的平均流量、平均流速、最大流速均无统计学差异(P>0.05);男性在不同年龄组间,其脑脊液的平均流量、平均流速、最大流速均无统计学差异(P>0.05);女性在不同年龄组间,其脑脊液的平均流量、平均流速、最大流速均无统计学差异(P>0.05)。结论在21-60岁的正常成人中,其中脑导水管层面脑脊液流动的MR测量具有良好的可重复性,其平均流量、平均流速、最大流速均不受年龄和性别影响。

Objective To conduct MRI measurement of midbrain aqueductal cerebrospinal fluid(CSF)waveform,velocity and flux in normal adults with different ages and genders.Methods 80 healthy volunteers aged 21-60 years old were scanned with phase contrast CSF-QF sequence by using Philips 1.5T MR machine.They were divided into four groups according to age:21-30 years old group,31-40 years old group,41-50 years old group and 51-60 years old group,with 20 persons(including 10 males and 10 females)in each group.The flow velocity code is 12cm/s.The average flow velocity,average flow flux and maximum flow velocity of CSF in midbrain aqueduct were measured by two MR operators independently using flow analysis software.Results CSF flow waveforms in midbrain aqueduct in all volunteers were smooth sine wave.The consistency test showed that the data from the two testers were consistent(the reliability coefficient was 0.97-0.99),and the average value from these two data was taken for statistical analysis.There was no statistical difference of CSF average flow velocity,average flow flux and maximum flow velocity between male and female among all four age groups(P>0.05),and also no statistical difference among all four age groups for males or females(P>0.05).Conclusion MRI measurement of midbrain aqueductal CSF waveform,velocity and flux in normal adults aged 21-60 years old has good repeatability.The average flow velocity,average flow flux and maximum flow velocity of CSF in midbrain aqueduct are not affected by age and gender,which can provide normal reference for brain disease research.