耐药肺结核患者的危险因素分析

Analysis of the risk factors in patients with drug-resistant pulmonary tuberculosis

目的了解肺结核患者发生耐药的相关危险因素,为今后结核病疫情防控工作提供参考意见。方法收集2018年1月—2020年12月海南医学院第二附属医院收治的符合本研究条件的657例肺结核患者的相关资料,分析造成肺结核患者发生耐药的危险因素。结果657例肺结核患者中有283例(43.07%)出现耐药性,二元Logistic回归分析结果提示治疗史(OR=6.062,95%CI 4.224~8.700)和肺部支气管扩张(OR=1.861,95%CI 1.172~2.957)是造成肺结核患者发生耐药的独立危险因素(OR>1,P<0.05)。结论肺结核患者耐药情况较为严重,复治和肺部支气管扩张是其主要威胁,在结核病的防治过程中应对耐药肺结核患者给予重点关注,减少耐药肺结核的产生。

Objective The relevant risk factors of drug resistance in tuberculosis patients were analyzed to provide reference opinions for the tuberculosis epidemic prevention and control work in the future.Methods Relevant data of pulmonary TB patients eligible for this study from 2018 to 2020,and analysis of risk factors for drug resistance in pulmonary TB patients were collected.Results A total of 657 pulmonary TB patients met the requirements of this study,of which 283 patients(43.07%)were drug-resistant.The results of binary logistic regression analysis suggested that treatment history(OR=6.062,95%CI 4.224-8.700)and pulmonary bronchiectasis(OR=1.861,95%CI 1.172-2.957)were risk factors for drug resistance in pulmonary TB patients.Conclusion Patients with tuberculosis have a serious drug resistance situation,and retreatment and pulmonary bronchiectasis are the main threats,and such population should be emphasized in the prevention and treatment of tuberculosis,reduce the production of drug-resistant pulmonary tuberculosis.