复方菝葜颗粒联合长春瑞滨加顺铂方案治疗晚期非小细胞肺癌的临床疗效观察

The clinical effect of the Fufang Baqia granules plus navelbine-cisplatinum chemotherapy regimen on advanced non-small cell lung cancer

目的:2020年全球癌症流行病学数据库统计报告提供了全球癌症负担的最新情况,肺癌约占11.4%,且为癌症死亡的主要原因,预计未来4年,癌症的负担将会持续加重。在每年的肿瘤新增病例中,肺癌占绝大多数,其发病率稳居高位。随着现代医学的不断发展,肿瘤的治疗方式也呈现多样化,中药复方制剂联合化疗治疗Ⅲ~Ⅳ期非小细胞肺癌(Non-Small Cell Lung Cancer,NSCLC)不失为一种具有良好疗效的治疗方案之一。因此,本研究旨在观察复方菝葜颗粒联合NP(长春瑞滨加顺铂)方案化疗治疗Ⅲ~Ⅳ期NSCLC的临床疗效观察。方法:将72例经病理组织学或细胞生物学确诊的Ⅲ~Ⅳ期NSCLC患者分为化疗组和联合组,化疗组患者根据具体情况给予NP方案化疗,联合组则是在NP方案的基础上联合口服复方菝葜颗粒治疗。结果:两组病例治疗后肿瘤疗效评价差异无统计学意义(P> 0.05),但联合组的疾病有效率却明显高于化疗组,对于临床用药有一定的指导意义。治疗后两组患者卡氏功能状态评分法(Karnofsky Performance Status,KPS)评分差异有统计学意义(P<0.05)。联合组骨髓抑制、乏力、恶心呕吐、神经毒性等不良反应发生率明显低于化疗组,差异有统计学意义(P <0.05)。结论:复方菝葜颗粒联合NP方案化疗能够起到减毒增效的作用,可提高患者的生活质量,减轻化疗所带来的不良反应。

Objective:The Global Cancer 2020(GLOBOCAN)Statistics report provides an update on the global cancer burden,with lung cancer accounting for 11.4%and the leading cause of cancer deaths,which is expected to continue to increase over the next four years.In the annual new cases of cancer,lung cancer accounts for the vast majority,the incidence rate remains high.With the continuous development of modern medicine,the treatment methods of tumor are also diversified.Chinese medicinal materials compound preparation combined with chemotherapy for stage Ⅲ~Ⅳ non-small cell lung cancer is one of the therapeutic options with good efficacy.Therefore,the goal of this study is to observe the clinical efficacy of the Fufang Baqia granules(复方菝葜颗粒)combined with NP regimen in the treatment of stage Ⅲ~Ⅳ non-small cell lung cancer.Methods:A total of 72 patients with stage Ⅲ~Ⅳ non-small cell lung cancer confirmed by hihiology or cell biology were divided into the chemotherapy group and the combination group.Patients in the chemotherapy group were given NP(vinorelbine plus cisplatin)regimen according to specific conditions,while patients in the combination group were treated with NP regimen combined with oral administration of the Fufang Baqia granules.Results:There was no statistically significant difference in the evaluation of tumor efficacy between the two groups after treatment(P>0.05),but the disease improvement rate in the combination group was significantly higher than the chemotherapy group,which had a certain guiding significance for clinical drug use.After treatment,the difference of KPS score between the two groups was statistically significant(P<0.05).The incidence of myelosuppression,fatigue,nausea and vomiting,neurotoxicity and other adverse reactions in the combination group was significantly lower than the chemotherapy group,and the differences were statistically significant(P<0.05).Conclusion:The Fufang Baqia granules combined with NP regimen can reduce toxicity and increase efficacy,improve patients'quality of life and reduce adverse reactions caused by chemotherapy.