盐酸司他斯汀片和糠酸莫米松鼻喷雾剂治疗变应性鼻炎的效果及安全性对比

Comparison of efficacy and safety of statin hydrochloride tablets and mometasone furoate nasal spray in the treatment of allergic rhinitis

目的比较变应性鼻炎(allergic rhinitis,AR)患者采用盐酸司他斯汀片与糠酸莫米松鼻喷雾剂治疗的效果与安全性。方法选取2021年1—12月于兴国县人民医院治疗的60例变应性鼻炎患者作为研究对象,按随机数字表法分为实验组与参照组,每组30例,实验组给予盐酸司他斯汀片治疗,参照组给予糠酸莫米松鼻喷雾剂治疗,对比2组患者治疗后AR症状评分、体征评分、不良反应发生情况、治疗总有效率。结果治疗后实验组的体征评分、各项症状评分均较参照组略低,但差异无统计学意义(P>0.05);治疗前后,2组间白细胞介素-13(interleukin-13,IL-13)、干扰素-γ(interferon-γ,IFN-γ)、C-反应蛋白(C-reactive protein,CRP)水平相比,差异无统计学意义(P>0.05);治疗后2组IL-13、CRP水平均较治疗前更低,IFN-γ水平更高,差异有统计学意义(P<0.05);2组疲劳、胃肠道反应、鼻部瘙痒、轻微鼻部出血总发生率比较,差异无统计学意义(P>0.05);实验组治疗总有效率较参照组高,但差异无统计学意义(P>0.05)。结论通过对变应性鼻炎患者实施盐酸司他斯汀片、糠酸莫米松鼻喷雾剂治疗均可较为有效地改善患者症状表现,提升治疗效率,抑制炎症反应,且安全性差异无统计学意义,临床医师可根据具体情况及患者意愿选择相应药物治疗。

Objective To analyze and compare the efficacy and safety of statin hydrochloride tablets and mometasone furoate nasal spray in the treatment of AR.Methods 60 patients with allergic rhinitis who were treated in Xingguo County People's Hospital from January to December 2021 were selected as the research objects,and were divided into the experimental group and the reference group according to the random number table method,with 30 cases in each group.The experimental group was treated with stillastine hydrochloride tablets,and the reference group was treated with mometasone furoate nasal spray.After treatment,the AR symptom score,sign score,adverse reactions and total effective rate of treatment of the two groups of patients were analyzed and compared.Results The physical sign scores and various symptom scores of the experimental group were slightly lower than those of the control group patients,but the data difference was not statistically significant(P>0.05).There was no significant difference in IL-13,IFN-γand CRP levels between the two groups before and after treatment(P>0.05).After treatment,IL-13 and CRP after treatment were lower than before treatment,and IFN-γwas higher in two groups,the difference was statistically significant(P<0.05).There was no statistically significant difference in the total incidence of adverse reactions such as fatigue,gastrointestinal reactions,nasal itching,and mild nasal bleeding between the two groups(P>0.05).The effective rate of treatment in the experimental group was higher than that in the control group,but the difference in data was not statistically significant(P>0.05).Conclusion Stastine hydrochloride tablets and mometasone furoate nasal spray can effectively improve the symptoms of patients with allergic rhinitis,improve treatment efficiency,and inhibit inflammation,and the safety difference is not statistically significant.Clinicians can choose the appropriate drugs according to the specific conditions and patients'wishes.