左心室辅助装置置入同期干预术前严重二尖瓣反流的现状及研究进展

Concomitant intervention for significant preoperative mitral regurgitation during left ventricular assist device implantation:current state and perspectives

全球心力衰竭(heart failure,HF)的患病率日益增长,二尖瓣反流(mitral regurgitation,MR)是终末期HF患者的常见表现。目前,左心室辅助装置(left ventricular assist device,LVAD)置入同期手术干预术前严重MR的适应证仍有较多争议。本文在论述终末期HF患者功能性MR的病因、分型及病理生理学的基础上,针对影响此类患者预后的相关因素及LVAD置入是否同期手术干预术前严重MR的相关研究进展作简要综述,以期为临床实践提供进一步参考依据。

The prevalence of heart failure(HF)is increasing worldwide,and mitral regurgitation(MR)is a common manifestation in patients with end-stage HF.Currently,the indications for concomitant surgical intervention of significant preoperative MR during left ventricular assist device(LVAD)implantation are still controversial.Based on discussing the etiology,classification,and pathophysiology of functional MR in patients with end-stage HF,this paper reviews the relevant factors affecting the prognosis of such patients and the progress of research related to whether to perform mitral valve surgery to intervene in significant MR during LVAD implantation,to provide a further reference for clinical practice.