β-Klotho在物质能量代谢及肿瘤发展中的作用

Research Progress ofβ-Klotho in Energy Metabolism and Tumor Development

β-Klotho(KLB)是Klotho蛋白家族中一员,主要分布在肝、脂肪、胰腺、大脑等器官和组织。KLB是一种单次跨膜蛋白质,也是成纤维细胞生长因子19/21(FGF19/21)靶向激活成纤维细胞生长因子受体(FGFRs)的关键的高亲和力共受体。KLB在FGF21/19-KLB-FGFRs通路中参与机体对血糖、脂质、体重、胆汁酸循环等物质能量的调节,参与多种组织器官中细胞增殖的调节。本文将对KLB的结构特征和分布,以及在FGF19/21-KLB-FGFRs通路中对物质能量的调节作用和肿瘤形成中的作用进行综述。

β-Klotho(KLB)is a member of the Klotho protein family,which is mainly distributed in organs and tissues such as the liver,fat,pancreas,and brain.KLB is a single-pass transmembrane protein whose structural characteristics determine that KLB acts as a co-receptor for fibroblast growth factor(FGF)19/21 targeting the activation of fibroblast growth factor receptor(FGFRs).KLB is involved in the regulation of blood glucose,lipids,body weight,bile acid circulation,and hepatocyte proliferation in the FGF21/19-KLB-FGFRs pathway.This paperwill review the structural characteristics and distribution of KLB,as well as the regulatory mechanism of material energy and its role in tumor formation in the FGF19/21-KLB-FGFRs pathways.