巨噬细胞DHA代谢表型在非酒精性脂肪性肝炎发病过程中的作用

Macrographic phenotype of docosahexaenoic acid metabolism plays a role in nonalcoholic steatohepatitis

非酒精性脂肪性肝炎(NASH)是一种以肝细胞脂肪变、气球样变和小叶内炎症为病理学特征的慢性代谢应激性肝病。本文综述了肠道菌群来源性丁酸通过组蛋白去乙酰化酶(HDAC)/12/15-脂氧合酶(12/15-LOX)/maresin信号途径,对肝脏单核巨噬细胞系统二十二碳六烯酸(DHA)代谢表型的调控作用,以及由此恢复促炎症介质/maresin平衡并促进炎症“程序性消退”,在诱导NASH缓解中的意义。

Nonalcoholic steatohepatitis(NASH),with pathological characteristics of hepatic steatosis,ballooning,and lobular inflammation,reflects the chronic liver disases induced by metabolic stress.Here,we summarize the regulatory effect of gut microbia-derived butyrate on the docosahexaenoic acid(DHA)metabolic phenotype of hepatic mononuclear phagocyte system through HDAC/12/15-LOX/maresin signaling.Its role in NASH amelioration is further reviewed on the basis of proinflammatory mediators/maresins rebalancing and spontaneous resolution of inflammation.