宏基因组二代测序诊断惠普尔养障体重症肺炎一例报道并文献复习

Diagnosis of Tropheryma Whipplei Severe Pneumonia Using Metagenomic Next Generation Sequencing: a Case Report and Literature Review

惠普尔养障体(TW)重症肺炎是由TW感染引起的罕见病,传统检测方法不易获得其病原学证据,误诊率极高,故其早期诊断与治疗仍面临巨大挑战。宏基因二代测序(mNGS)可检测到传统检测手段无法检测到的罕见病原体,使得TW检出率不断提高。本文报道1例支气管肺泡灌洗液mNGS诊断为TW感染的重症肺炎患者,给予头孢曲松联合复方磺胺甲噁唑治疗,患者病情好转。

Tropheryma whipplei(TW)severe pneumonia caused by TW is a rare disease.Traditional detection methods are difficult to obtain its etiological evidence,resulting in the misdiagnosis rate is extremely high.Early diagnosis and treatment are still huge clinical challenges.Metagenomic next-generation sequencing(mNGS)can detect rare pathogens that cannot be detected by conventional detection methods,leading to an increasing detection rate of TW.This article reports one case of TW severe pneumonia diagnosed by mNGS,ceftriaxone combined with compound sulfamethoxazole was administered,and the patient had good prognosis.