乌司他丁联合生长抑素在急诊SAP患者中的应用效果

The application effect of ulinastatin combined with somatostatin in emergency SAP patients

目的探讨乌司他丁联合生长抑素在急诊重症急性胰腺炎(SAP)患者中的应用效果。方法选取2021年3月至2023年4月经莆田九十五医院急救医学科收治的SAP患者78例,按照随机数表法分为两组,每组各39例。对照组予以生长抑素单药泵注,观察组基于对照组用药条件施加乌司他丁治疗,比较两组患者疗效、症状缓解时间、用药前后机体炎症指标[C反应蛋白(CRP)、白细胞介素-6(IL-6)、白细胞介素-1β(IL-1β)]以及并发症。结果观察组方案疗效(总有效率为94.87%)优于对照组(76.92%)(χ^(2)=5.185,P=0.022)。观察组各症状(腹痛、腹胀、发热及恶心呕吐)缓解时间均短于对照组(P<0.05)。用药后,观察组患者3项机体炎症指标(CRP、IL-6及IL-1β)检测值均低于对照组(P<0.05)。观察组并发症总发生率(7.69%)低于对照组(25.64%)(χ^(2)=4.523,P=0.033)。结论乌司他丁与生长抑素配伍用于急诊SAP患者的治疗效果显著,并可加快症状控制,减轻机体炎症反应、减少并发症发生。

Objective To investigate the application effect of ulinastatin combined with somatostatin in emergency severe acute pancreatitis(SAP)patients.Methods A total of 78 SAP patients admitted to the Department of Emergency Medicine of Putian 95th Hospital from March 2021 to April 2023 were selected and divided into two groups using a random number table method,with 39 patients in each group.The control group was treated with a single drug infusion of somatostatin,while the observation group was treated with ulinastatin based on the medication conditions of the control group.The efficacy,symptom relief time,and inflammatory indicators of the body(C-reactive protein[CRP],interleukin-6[IL-6],and interleukin-1β[IL-1β])before and after treatment,as well as complications,were compared between the two groups.Results The therapeutic effect of the observation group(total effective rate of 94.87%)was higher than that of the control group(76.92%)(χ^(2)=5.185,P=0.022).The relief time of various symptoms(abdominal pain,abdominal distention,fever,nausea,and vomiting)in the observation group was shorter than that in the control group(P<0.05).After medication,the detection values of three inflammatory indicators(CRP,IL-6,and IL-1β)of the body of the observation group were lower than those of the control group(P<0.05).The total proportion of complications in the observation group(7.69%)was lower than that in the control group(25.64%)(χ^(2)=4.523,P=0.033).Conclusion The combination of ulinastatin and somatostatin has a significant therapeutic effect on emergency SAP patients,and can accelerate symptom control,reduce inflammation in the body,and reduce the occurrence of complications.