消积止咳口服液联合氨溴索口服液治疗小儿支原体肺炎的效果

Effect of Xiaoji Zhike oral liquid and ambroxol oral liquid in the treatment of mycoplasma pneumonia in children

目的:探讨消积止咳口服液辅助氨溴索口服液在小儿支原体肺炎治疗中的应用效果。方法:收集2020年6月—2022年9月在江西省南丰县人民医院接受治疗的支原体肺炎患儿50例,采用随机数字表法分为观察组和对照组各25例。两组均给予镇咳、化痰等基础治疗,在此基础上,对照组采用氨溴索口服液治疗:6个月~2岁,1.5mL/次;2~6岁,2.5mL/次;6~12岁,5mL/次;3次/d。观察组在对照组基础上联合消积止咳口服液治疗:1周岁以内,5mL/次;1~2岁,10mL/次;3~4岁,15mL/次;5岁以上,20mL/次;3次/d。两组均治疗2周。观察两组体温恢复正常时间、住院时间、症状消失时间、体液免疫水平、血清炎症指标和疗效。结果:观察组体温恢复正常时间、住院时间均短于对照组(P<0.05)。观察组咳嗽、肺部病灶、肺部啰音消失时间均早于对照组(P<0.05)。干预后,两组CD3^(+)、CD4^(+)水平较治疗前明显提高,且观察者高于对照组(P<0.05);而IgM、IgA水平则明显下降,且观察组低于对照组(P<0.05)。干预后,两组hs-CRP、IL-6水平低于同组干预前,且观察者低于对照组(P<0.05);而IL-10水平则高于同组干预前,且观察者高于对照组(P<0.05)。观察组总有效率为96.00%(24/25),高于对照组的72.00%(18/25,P<0.05)。结论:消积止咳口服液辅助氨溴索口服液治疗小儿支原体肺炎的效果较好,可以缩短患儿体温恢复正常时间、住院时间及症状消失时间,增强患儿体液免疫,提高治疗效果。

Objective:To investigate the application effect of Xiaoji Zhike oral liquid and ambroxol oral liquid in the treatment of mycoplasma pneumonia in children.Methods:Fifty children with mycoplasma pneumonia who were treated at the People’s Hospital of Nanfeng County,Jiangxi Province from June 2020 to September 2022 were collected,and a random number table method was used to divide them into an observation group and a control group with 25 cases each.Both groups were given basic treatment such as cough relieving and phlegm resolving.On this basis,the control group was treated with ambroxol oral solution:6 months to 2 years old,1.5 mL/dose;2-6 years old,2.5 mL/time;6-12 years old,5 mL/time;3 times/d.The observation group was treated with Xiaoji Zhike oral liquid on the basis of the control group:under 1 year old,5 mL/dose;1-2 years old,10 mL/time;3-4 years old,15 mL/time;over 5 years old,20 mL/time;3 times/d.Both groups were treated for 2 weeks.The time for body temperature recovering normal,hospitalization time,symptom disappearance time,humoral immune level,serum inflammatory indicators,and therapeutic effect were observed.Results:The time for body temperature recovering normal and hospitalization time in the observation group were lower than those in the control group(P<0.05).The disappearance times of cough,lung lesions,and lung rales in the observation group were earlier than those in the control group(P<0.05).After intervention,the levels of CD3^(+)and CD4^(+)in both groups were significantly increased compared to before treatment,and the observation group was higher than the control group(P<0.05);the levels of IgM and IgA significantly decreased,and the observation group was lower than the control group(P<0.05).After intervention,the levels of hs-CRP and IL-6 in both groups were lower than those in the same group before intervention,and the observation group was lower than those in the control group(P<0.05);the IL-10 level was higher than those before the intervention in the same group,and the observation group was higher than the control group(P<0.05).The total effective rate in the observation group was 96.00%(24/25),which was higher than 72.00%(18/25)in the control group(P<0.05).Conclusion:The application effect of Xiaoji Zhike oral liquid combined with ambroxol oral liquid in the treatment of mycoplasma pneumonia in children is effective,which can shorten the time for children’s body temperature recovering normal,hospitalization time,symptom disappearance time,and improve humoral immunity level,and enhance the treatment effect.