瞬时受体电位通道6在糖尿病肾病中作用的研究现状

Research status on the role of transient receptor potential cation channel 6 in diabetic kidney disease

糖尿病肾病(DKD)是引起终末期肾疾病(ESKD)的主要病因,也是1型和2型糖尿病的常见并发症。DKD主要表现为足细胞损伤、系膜细胞肥大和肾小球硬化,这些病理表现将导致肾纤维化,从而影响肾功能。瞬时受体电位通道6(TRPC6)是一种Ca^(2+)可渗透的非选择性阳离子通道,表达于大脑、平滑肌组织和肾等部位,对Ca^(2+)的渗透性很强。TRPC6通路在调节DKD中起着关键作用。本文通过论述TRPC6信号通路及其相关影响分子如血管紧张素Ⅱ(AngⅡ)、活化T细胞核因子(NFAT)、转化生长因子β(TGF-β)、核因子κB(NF-κB)等在足细胞损伤、系膜细胞损伤和肾纤维化中的具体机制,从而了解TRPC6通路与DKD的关系,以期为寻找治疗DKD的新方法提供思路和借鉴。

Diabetic kidney disease(DKD)is one of the main etiologies of end-stage renal disease(ESKD)and a familiar complication of type 1 and type 2 diabetes mellitus.The main pathological manifestations of DKD include podocyte injury,mesangial cell hypertrophy and glomerulosclerosis,which will lead to renal fibrosis and affect renal function.Transient receptor potential cation channel 6(TRPC6)is a Ca^(2+)permeable non-selective cation channel,which is expressed in the brain,smooth muscle tissue and kidney,and has a strong permeability to Ca^(2+).Numerous studies have found that TRPC6 pathway plays a key role in regulating diabetic nephropathy.This article discusses the specific mechanism of TRPC6 signaling pathway and its related influencing molecules such as angiotensinⅡ(AngⅡ),nuclear factor of activated T cells(NFAT),transforming growth factor beta(TGF-β)and nuclear factor kappa-B(NF-κB)in podocyte injury,mesangial cell injury and renal fibrosis,so as to understand the relationship between TRPC6 pathway and DKD,with a view to provide ideas and references for finding new approaches to treat DKD.