紧急宫颈环扎术后使用利托君及阿托西班治疗宫颈机能不全的临床疗效分析

Clinical effect analysis of ritodrine and atosiban in the treatment of cervical insufficiency after emergency cervix cerigation

目的 探究紧急宫颈环扎术后使用利托君及阿托西班治疗宫颈机能不全的临床疗效。方法 选取2020年5月至2022年2月收治的60例宫颈机能不全患者作为研究对象。采用随机数字表法分成对照A组、对照B组、试验C组,每组20例。3组均采用紧急宫颈环扎术,在手术治疗结束后对照A组采用盐酸利托君治疗,对照B组采用阿托西班治疗,试验C组在盐酸利托君基础上应用阿托西班治疗。分析并对比3组宫缩抑制效果、不良反应发生率、新生儿结局。结果 对照A组、试验C组的宫缩抑制率高于对照B组(P<0.05);试验C组术后并发症发生率低于对照A组、对照B组,差异有统计学意义(P<0.05);较之对照A组、对照B组,试验C组的胎儿丢失、新生儿窒息及低体重儿的新生儿结局发生率与对照A组、对照B组比较,差异无统计学意义(P>0.05)。与对照A组、对照B组比较,试验C组的延长孕周时间更长、新生儿Apgar评分更高,差异有统计学意义(P<0.05)。结论 对该疾病患者进行紧急宫颈环扎术后应用利托君以及阿托西班两种药物联合治疗有良好效果,可以更好地对宫缩起到抑制的效果,适当延长孕周,改善新生儿的结局与预后,降低孕妇药物不良反应。

Objective To explore the clinical efficacy of using rituximab and atoxiban in the treatment of cervical incompetence after emergency cervical cerclage surgery.Methods Sixty patients with cervical incompetence admitted from May 2020 to February 2022 were selected as the study subjects.Divide into control group A,control group B,and trial group C using random number table method,with 20 cases in each group.All three groups underwent emergency cervical cerclage surgery.After the surgical treatment,control group A received treatment with rituximab hydrochloride,control group B received treatment with atoxiban,and experimental group C received treatment with atoxiban on the basis of rituximab hydrochloride.Analyze and compare the inhibitory effects of uterine contractions,incidence of adverse reactions,and neonatal outcomes among three groups.Results The inhibition rate of uterine contractions in control group A and test group C was higher than that in control group B(P<0.05);The incidence of postoperative complications in experimental group C was lower than that in control group A and control group B,with a statistically significant difference(P<0.05);Compared with control group A and control group B,the incidence of fetal loss,neonatal asphyxia,and low birth weight infant outcomes in experimental group C was not statistically significant(P>0.05).Compared with control group A and control group B,experimental group C had a longer gestational week extension and a higher Apgar score for newborns,with statistically significant differences(P<0.05).Conclusion The combination treatment of rituximab and atoxiban after emergency cervical cerclage surgery for this disease has good effects,can better inhibit uterine contractions,appropriately prolong gestational age,improve neonatal outcomes and prognosis,and reduce adverse drug reactions in pregnant women.