淋巴血浆置换加半全血置换治疗术后感染导致贫血的疗效观察

Observation on the therapeutic effect of LPE combined with semi whole blood replacement for postoperative anemia caused by infection

目的观察淋巴血浆置换(LPE)加半全血置换术对术后严重感染导致患者伴中、重度贫血的治疗效果。方法收集30例术后发生严重感染,伴中、重度贫血,抗生素治疗48~72 h无效符合标准的患者,观察组(n=15)行LPE加半全血置换术治疗联合抗生素治疗,对照组(n=15)行常规抗生素抗感染、输血治疗。对两组治疗前后感染、贫血评价观察指标组间、组内比较,评价治疗效果。结果治疗前两组感染、贫血观察指标比较差异无统计学意义(P>0.05)。观察组感染、贫血观察评价指标治疗前后组内比较差异有统计学意义(P<0.05)。对照组治疗前后组内比较,WBC、NEUT、NEU观察指标无明显下降,且CRP、PCT观察指标呈上升趋势,RBC、Hb、HCT无明显上升,差异无统计学意义(P>0.05)。每次治疗后两组感染、贫血评价观察指标组间比较,差异有统计学意义(P<0.05);结论LPE加半全血置换术治疗术后严重感染,伴中、重度贫血治疗方案优于单纯抗生素抗感染,输血改善贫血症状的常规治疗方案。

Objective To observe the therapeutic effect of lymphatic plasma therapy(LPE)combined with semi whole blood exchange on patients with moderate to severe anemia caused by severe postoperative infection.Methods Thirty patients who developed severe postoperative infections with moderate to severe anemia and were treated with antibiotics for 48 to 72 hours but failed to meet the criteria were divided into an observation group(LPE combined with semi whole blood replacement surgery and antibiotic treatment,n=15)and a control group(conventional antibiotic anti infection and blood transfusion treatment,n=15).Evaluation indicators of infection and anemia between and within two groups before and after treatment,and the treatment effect were compared,respectively.Results There was no statistically significant difference in the observation indicators of infection and anemia between the two groups before treatment(P>0.05);After each treatment,there was a statistically sig-nificant difference in the evaluation and observation indicators of infection and anemia between the two groups(P<0.05);Observation group:There was a statistically significant difference in the observation and evaluation in-dicators of infection and anemia before and after treatment within the group(P<0.05);Control group:Compared within the group before and after treatment,there was no significant decrease in WBC,NEUT,and NEU observation indicators,and CRP and PCT observation indicators showed an upward trend,while RBC,HBG,and HCT did not show a significant increase.The difference was not statistically significant(P>0.05);Conclusions The com-bination of LPE and semi whole blood replacement surgery is superior to the conventional treatment regimen of anti-biotics alone for anti-infection and blood transfusion to improve anemia symptoms in the treatment of postoperative severe anemia.