人参五味子汤加减对肺炎支原体感染致大叶性肺炎(肺脾气虚证)患儿的疗效及炎症指标的影响

The effect of modified ginseng and schisandra decoction on the efficacy and inflammatory indicators of children with lobar pneumonia(lung spleen deficiency syndrome)caused by mycoplasma pneumonia infection

目的探讨人参五味子汤加减对肺炎支原体感染致大叶性肺炎(肺脾气虚证)患儿的临床疗效及炎症指标的改善作用。方法选取2020年1月至2022年7月吉林省中医药科学院第一临床医院收治的84例支原体感染致大叶性肺炎(肺脾气虚证)患儿,利用随机数字表法分为两组各42例。常规组按照传统治疗方案进行治疗,联合组在传统治疗方案基础上加用人参五味子汤加减进行治疗。7 d后比较两组患儿的中医证候积分、临床疗效、炎症指标、总不良反应发生率差异。结果联合组治疗后的中医证候积分、炎症指标低于常规组(P<0.05),临床疗效等级分布优于常规组(P<0.05),总有效率高于常规组(P<0.05),总不良反应发生率与常规组无差异(P>0.05)。结论在肺炎支原体感染致大叶性肺炎(肺脾气虚证)患儿治疗中人参五味子汤加减疗效肯定、安全性好,值得推广。

Objective To explore the clinical efficacy of ginseng schisandra decoction in children with lobar pneumonia(lung spleen deficiency syndrome)induced by mycoplasma pneumoniae infection and improvement of inflammatory indicators.Method 84 children with lobar pneumonia(lung spleen deficiency syndrome)caused by mycoplasma infection admitted to the First Clinical Hospital of Jilin Academy of Traditional Chinese Medicine from January 2020 to July 2022 were selected and randomly divided into two groups with 42 cases each.The conventional group was treated according to the traditional treatment plan,while the combined group was treated with ginseng and schisandra decoction in addition to the traditional treatment plan.After 7 days,compare the differences in traditional Chinese medicine syndrome scores,clinical efficacy,inflammatory indicators,and total incidence of adverse reactions between the two groups of children.Result The results showed that the traditional Chinese medicine syndrome score and inflammatory indicators in the combined group were lower than those in the conventional group(P<0.05),and the clinical efficacy level distribution was better than that in the conventional group(P<0.05).The total effective rate was higher than that in the conventional group(P<0.05),and there was no difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion In the treatment of children with lobar pneumonia(lung spleen deficiency syndrome)caused by Mycoplasma pneumoniae infection,the modified Ginseng Wuweizi decoction has a positive therapeutic effect and good safety,and is worth promoting.