脂联素受体1调控小胶质细胞参与阿尔兹海默病发病机制的研究进展

Research progress on adiponectin receptor 1 in the pathogenesis of Alzheimer disease through regulating microglia

阿尔茨海默病(Alzheimer Disease, AD)是一种进行性加重的神经系统退行性疾病,是最为常见的痴呆症类型。越来越多的研究表明,小胶质细胞在AD病理生理过程中发挥重要功能,但小胶质细胞参与AD发病的具体机制尚不完全清楚。最近,脂联素(adiponectin, APN)/脂联素受体1(adiponectin receptor 1, AdipoR1)信号被证明具有抗炎作用,并与学习和记忆密切相关。研究发现,AdipoR1可表达于小胶质细胞,其可能通过调节小胶质细胞的功能活动来参与AD的发生和发展。因此,本文旨在对APN、AdipoR1和小胶质细胞在AD的发病和治疗中的作用以及AdipoR1参与调节小胶质细胞功能的研究进展进行综述。

Alzheimer disease(AD)is a progressively worsening neurodegenerative disease and is the most common type of dementia.A growing number of studies have shown that microglia play an important function in the pathophysiology of AD,but the specific mechanisms by which microglia are involved in the pathogenesis of AD are not fully understood.Recently,adiponectin(APN)/adiponectin receptor 1(AdipoR1)signaling has been shown to have anti-inflammatory effects and to be closely associated with learning and memory.It has been found that AdipoR1 can be expressed in microglia.It may be involved in the onset and development of AD by regulating the functional activity of microglia.Therefore,the aim of this paper is to review the research progress on the role of APN,AdipoR1 and microglia in the pathogenesis and treatment of AD,and the involvement of AdipoR1 in the regulation of microglia function.