达立通颗粒运用网络药理学对功能性消化不良作用机制的探讨

Exploration of the Mechanism of Action of Dalitong Granules on Functional Dyspepsia Using Network Pharmacology

目的:达立通颗粒运用网络药理学研究和分子对接技术研究其功能性消化不良(Functional dyspepsia,FD)的作用机制。方法:应用TCMSP等数据库筛选达立通颗粒中各药物主要活性化学成分与FD靶点相关性,构建“中药-化学成分-靶基因-疾病”网络,再构建蛋白互作关系网络,GO功能富集与KEGG信号通路富集,最后进行分子对接。结果:筛选出的活性化学成分与功能性消化不良共有133个靶点,通过125条通路作用于功能性消化不良。结论:达立通颗粒通过多成分,多靶点,多通路治疗FD。

Objective:A cyberpharmacology study and molecular docking technique were utilized to investigate the mechanism of action of Dalitong Granules in functional dyspepsia(FD).Methods:Traditional Chinese Medicine Systems Pharmacology(TCMSP)databaseand other databases were used to screen the correlation between the main active chemical components of each drug in Dalitong Granules and FD targets.The'traditional Chinese medicine-chemical composition-target gene-disease'network was constructed,and the protein interaction network was constructed.Then GO functional enrichment with KEGG signaling pathway enrichment and finally molecular docking.Results:The screened active chemical components and functional dyspepsia had a total of 133 targets,which acted on functional dyspepsia through 125 pathways.Conclusion:TDalitong Granules treat FD through a multi-component,multi-target,multi-pathway approach.