北京地区表观健康人群同型半胱氨酸水平调查

Survey of serum homocysteine levels of apparently healthy subjects in Beijing

目的调查北京地区表观健康人群血清(Hcy)同型半胱氨酸水平分布情况。方法选取2018年6月—2020年6月空军特色医学中心表观健康者10807名,检测血清Hcy水平,按年龄(≤30岁、31~40岁、41~50岁、51~60岁、61~70岁和71~93岁)和性别分别进行分组分析。采用Deming回归分析评估Hcy水平与年龄的相关性。结果北京地区10807名表观健康者血清Hcy水平为2.3~141.7μmol/L,中位数为12.1μmol/L。≤30岁组与31~40岁组和41~50岁组、51~60岁组与61~70岁组血清Hcy水平差异无统计学意义(P>0.05),其他各年龄组之间血清Hcy水平差异均有统计学意义(P<0.05)。男性总Hcy水平和各年龄组Hcy水平均显著高于女性(P<0.001)。在男性表观健康者中,≤30岁组与61~70岁组、31~40岁组与41~50岁组、51~60岁组与61~70岁组Hcy水平差异无统计学意义(P>0.05),其他各组之间Hcy水平差异均有统计学意义(P<0.001)。在女性表观健康者中,≤30岁组与41~50岁组Hcy水平差异无统计学意义(P>0.05),其他各组之间Hcy水平差异均有统计学意义(P<0.001)。以现行的Hcy参考区间(5~15μmol/L)为标准,表观健康者的高同型半胱氨酸血症(HHcy)检出率为21.2%;以新建立的男、女性Hcy参考区间为标准,男性、女性HHcy检出率分别为2.3%、0.2%。结论北京地区表观健康人群血清Hcy水平存在性别和年龄差异,建议分性别和年龄分别建立相应的参考区间。≤30岁的表观健康人群血清Hcy水平处于较高水平。

Objective To investigate the distribution of serum homocysteine(Hcy)levels of apparently healthy subjects in Beijing.Methods A total of 10807 apparently healthy subjects from the Air Force Medical Center from June 2018 to June 2020 were enrolled to determine serum Hcy levels.They were classified according to ages(≤30 years old,31-40 years old,41-50 years old,51-60 years old,61-70 years old and 71-93 years old)and sex.Deming regression analysis was used to evaluate the correlation between Hcy and age.Results Serum Hcy of 10807 apparently healthy subjects in Beijing ranged from 2.3 to 141.7μmol/L,and the median was 12.1μmol/L.There was no statistical significance in serum Hcy level between≤30 and 31-40 years old groups and 41-50,51-60 and 61-70 years old groups(P>0.05),and there was statistical significance in serum Hcy level for the other age groups(P<0.05).The total Hcy level in males and Hcy level in all age groups were higher than those in females(P<0.001).In apparently healthy males,there was no statistical significance in serum Hcy level between≤30 and 61-70 years old groups,between 31-40 and 41-50 years old groups and between 51-60 and 61-70 years old groups(P>0.05),but there was statistical significance for the other groups(P<0.001).In apparently healthy females,there was no statistical significance in Hcy level between≤30 and 41-50 years old groups(P>0.05),but there was statistical significance for the other groups(P<0.001).According to the current Hcy reference interval(5-15μmol/L),the determination rate of hyperhomocysteinemia(HHcy)in apparently healthy subjects was 21.2%.According to the established reference intervals for males and females,the determination rates of HHcy were 2.3%for males and 0.2%for females.Conclusions There are sex and age differences in serum Hcy levels among apparently healthy subjects in Beijing.It is recommended to establish corresponding reference intervals based on sex and ages.Apparently healthy subjects aged≤30 have high levels of serum Hcy.