近红外光协同免疫疗法增强抗肿瘤效果研究进展

Research progress of near-infrared light synergistic immunotherapy for enhancing anti-cancer effect

肿瘤免疫疗法虽然在一定程度上克服了传统疗法存在的复发可能性大的问题,但也存在应答率低、部分患者不良反应大的局限性.近红外光可以直接或间接激活免疫系统,且可实时成像进而监测治疗效果及评估在治疗过程中产生的不良反应,因此近红外光协同下的免疫疗法可增强抗肿瘤效果、降低各自单独使用时所引起的不良反应,是一种非常有前景的治疗方法.故对近年来近红外光协同的免疫激活治疗肿瘤的设计策略、应用、问题及对策方面进行了综述.

Although tumor immunotherapy can reduce the possibility of recurrence of cancer of traditional chemotherapy,it has a low response rate for some poorly immunogenic tumors.Near infrared light can directly or indirectly activate the immune system,monitor the treatment effect and evaluate the adverse reactions through real-time imaging in the treatment process.Therefore,near infrared light combined with immunotherapy not only enhances the anticancer effect,but also reduces the adverse reactions,which has potential clinical application value.This review summaried the design strategy,application,problems and countermeasures of near-infrared light synergistic immune activation in the treatment of tumors.