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钆塞酸二钠增强MRI评估肝硬化患者肝功能的研究进展

Research Progress of Gd-EOB-DTPA Enhanced MRI in Evaluating Liver Function in Liver Cirrhosis
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摘要 肝功能可反映肝硬化严重程度,对病情监测、疗效评估及手术风险预测具有重要临床价值。目前临床上评价肝功能的常用方法包括血液生化检查、药物排泄试验、综合评分系统及常规影像学检查等,这些方法各有其局限性。钆塞酸二钠是肝细胞特异性造影剂,由肝细胞摄取和排泄,可以直接反映肝功能。因此,通过钆塞酸二钠增强MRI有望实现无创节段性定量肝功能评估,这也是目前研究的热点。本文就钆塞酸二钠增强MRI评估肝功能的方法进行综述,探讨其评估肝硬化肝功能的可行性。 Liver function can reflect the severity of cirrhosis,and has important clinical value for disease monitoring,efficacy evaluation and surgical risk prediction.At present,the methods commonly used in clinical evaluation of liver function include blood biochemical examination,drug excretion test,comprehensive scoring system and routine imaging examination.All these methods have their limitations.Gd-EOB-DTPA is a hepatocellular specific contrast agent,which is taken up and excreted by liver cells and can directly reflect liver function.Therefore,it is expected to achieve non-invasive segental quantitative evaluation of liver function through enhanced MRI of Gd-EOB-DTPA,which is the focus of current research.In this paper,the methods of Gd-EOB-DTPA enhanced MRI for liver function assessment were reviewed,and the feasibility of Gd-EOB-DTPA in liver function assessment was discussed.
作者 张岩 冯汉 宋梦晨 曹国洪 ZHANG Yan;FENG Han;SONG Mengchen;CAO Guohong(Shulan(Hangzhou)Hospital,Hangzhou 310000,China;不详)
出处 《中国医学影像学杂志》 CSCD 北大核心 2023年第12期1328-1331,共4页 Chinese Journal of Medical Imaging
基金 浙江省自然科学基金(LGF19H180004)。
关键词 肝硬化 磁共振成像 造影剂 钆塞酸二钠 肝功能 综述 Liver cirrhosis Magnetic resonance imaging Contrast media Gd-EOB-DTPA Liver function Review
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