超声联合超声微泡介导的药物递送策略在肿瘤治疗中的研究进展

Research Progress of Ultrasound Combined with Ultrasound Microbubble Mediated Drug Delivery Strategy in Tumor Therapy

超声除在成像方面的临床应用外,作为一种促进药物递送的工具也已得到深入研究。低频超声与微泡结合,可以透过不同的生物屏障,增强药物的靶向输送,这种能力有助于超声波与临床治疗结合。本文对超声波生物效应、超声微泡的特征及超声靶向微泡破坏技术在肿瘤治疗中的研究进展进行综述。

Nowadays,the application of ultrasound is not only used in clinical imaging,but also extended in the study of drug delivery.Diagnostic ultrasound combined with microbubbles can effectively open the biological barriers,which can enhance the targeted delivery of drugs and be beneficial to the combination of ultrasound and disease treatment.This review summarizes the biological effects of ultrasound,the characteristics of ultrasound microbubbles and the potential ability that solving the biological barrier problems in cancer therapy by using ultrasound targeted microbubble destruction,hoping to provide some reference for the further development of therapeutic ultrasound as a safe and effective drug targeted delivery strategy.